open access

Vol 76, No 6 (2018)
Original articles
Published online: 2018-02-02
Submitted: 2017-12-07
Accepted: 2018-01-31
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Prevalence, diagnosis, and treatment of familial hypercholesterolaemia in outpatient practices in Poland

Krzysztof Chlebus, Barbara Cybulska, Marcin Gruchała, Anna Smaga, Katarzyna Wróbel, Bogdan Wojtyniak, Marcin Pajkowski, Piotr Jankowski, Tomasz Zdrojewski
DOI: 10.5603/KP.a2018.0053
·
Kardiol Pol 2018;76(6):960-967.

open access

Vol 76, No 6 (2018)
Original articles
Published online: 2018-02-02
Submitted: 2017-12-07
Accepted: 2018-01-31

Abstract

Background: Familial hypercholesterolaemia (FH) is the most common genetic disease leading to premature atherosclerosis.

Aim: The aim of the study was to evaluate the prevalence, diagnosis, and treatment of FH in outpatient practices in Poland.

Methods: The study included a representative sample of 147 primary care physicians, cardiologists, and diabetologists caring for 2812 adult patients with hypercholesterolaemia and low-density lipoprotein cholesterol (LDL-C) level > 1.8 mmol/L, who were treated with statins or did not receive statins due to intolerance or contraindications. The physicians declared whether they diagnosed FH in the study group. In addition, we evaluated the Dutch Lipid Clinic Network (DLCN) diagnostic criteria for FH in all patients. The results were weighted and extrapolated to the general outpatient population in Poland. Treatment and its effectiveness were also evaluated.

Results: FH6+ score by the DLCN criteria was found in 3.6% of the study group, which translates by extrapolation to 136,300 adult patients with FH in Poland. Among patients with FH6+, this diagnosis was correctly made by physicians in 25% of cases and was not established in 75% of cases. Only 32.8% of patients received high statin doses. High LDL-C levels were found in a large proportion of patients, including levels ≥ 5.0 mmol/L in 42.7% of patients and ≥ 4.1 mmol/L in 59.7% of patients.

Conclusions: Familial hypercholesterolaemia is inadequately diagnosed and treated in Poland, which calls for a radical im­provement of pre- and postgraduate education in this regard.

Abstract

Background: Familial hypercholesterolaemia (FH) is the most common genetic disease leading to premature atherosclerosis.

Aim: The aim of the study was to evaluate the prevalence, diagnosis, and treatment of FH in outpatient practices in Poland.

Methods: The study included a representative sample of 147 primary care physicians, cardiologists, and diabetologists caring for 2812 adult patients with hypercholesterolaemia and low-density lipoprotein cholesterol (LDL-C) level > 1.8 mmol/L, who were treated with statins or did not receive statins due to intolerance or contraindications. The physicians declared whether they diagnosed FH in the study group. In addition, we evaluated the Dutch Lipid Clinic Network (DLCN) diagnostic criteria for FH in all patients. The results were weighted and extrapolated to the general outpatient population in Poland. Treatment and its effectiveness were also evaluated.

Results: FH6+ score by the DLCN criteria was found in 3.6% of the study group, which translates by extrapolation to 136,300 adult patients with FH in Poland. Among patients with FH6+, this diagnosis was correctly made by physicians in 25% of cases and was not established in 75% of cases. Only 32.8% of patients received high statin doses. High LDL-C levels were found in a large proportion of patients, including levels ≥ 5.0 mmol/L in 42.7% of patients and ≥ 4.1 mmol/L in 59.7% of patients.

Conclusions: Familial hypercholesterolaemia is inadequately diagnosed and treated in Poland, which calls for a radical im­provement of pre- and postgraduate education in this regard.

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Keywords

familial hypercholesterolaemia, epidemiology, outpatient practice, survey

About this article
Title

Prevalence, diagnosis, and treatment of familial hypercholesterolaemia in outpatient practices in Poland

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 76, No 6 (2018)

Pages

960-967

Published online

2018-02-02

DOI

10.5603/KP.a2018.0053

Bibliographic record

Kardiol Pol 2018;76(6):960-967.

Keywords

familial hypercholesterolaemia
epidemiology
outpatient practice
survey

Authors

Krzysztof Chlebus
Barbara Cybulska
Marcin Gruchała
Anna Smaga
Katarzyna Wróbel
Bogdan Wojtyniak
Marcin Pajkowski
Piotr Jankowski
Tomasz Zdrojewski

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