open access

Vol 76, No 6 (2018)
Original articles
Published online: 2018-01-26
Submitted: 2017-09-05
Accepted: 2017-11-27
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Postoperative kinetics of common inflammatory biomarkers after congenital heart defect procedures with extracorporeal circulation in children

Ireneusz Haponiuk, Radosław Jaworski, Konrad Paczkowski, Maciej Chojnicki, Mariusz Steffens, Aneta Szofer-Sendrowska, Katarzyna Gierat-Haponiuk, Ewelina Kwaśniak, Marta Paśko-Majewska, Katarzyna Leszczyńska, Jacek Zieliński, Wiktor Szymanowicz
DOI: 10.5603/KP.a2018.0038
·
Kardiol Pol 2018;76(6):968-973.

open access

Vol 76, No 6 (2018)
Original articles
Published online: 2018-01-26
Submitted: 2017-09-05
Accepted: 2017-11-27

Abstract

Background: Extracorporeal circulation is associated with systemic inflammatory response syndrome. Therefore, the diagnosis of infection should be differentiated from a typical postoperative course.

Aim: The aim of the study was to evaluate the kinetics of inflammatory biomarkers in children in the first days after cardiac surgery with extracorporeal circulation.

Methods: Prospective data were collected from 51 consecutive children referred for surgical treatment in Department of Paediatric Cardiac Surgery, St. Adalbertus Hospital in Gdańsk, between February and August 2015. Blood samples were collected on the first, second, and third postoperative days and sent to the institutional laboratory for routine investigations: white blood cell count, serum C-reactive protein (CRP) and procalcitonin concentrations.

Results: The highest levels of procalcitonin were on the first postoperative day (median 3.53 ng/mL), although the peak values of CRP concentration and white blood cell count were on the second postoperative day (96 mg/L and 17.3 G/L). In the group of patients with foreign material implantation (Contegra® or Gore-Tex®), the higher values of procalcitonin concentration and white blood cell count were measured in the subsequent postoperative days.

Conclusions: The kinetics of analysed inflammatory biomarkers on the first days after cardiac surgery for congenital heart disease in children have different characteristics. The knowledge about the kinetics of inflammatory biomarkers could be useful in determining the possibility of evolving infections in the early postoperative period.

Abstract

Background: Extracorporeal circulation is associated with systemic inflammatory response syndrome. Therefore, the diagnosis of infection should be differentiated from a typical postoperative course.

Aim: The aim of the study was to evaluate the kinetics of inflammatory biomarkers in children in the first days after cardiac surgery with extracorporeal circulation.

Methods: Prospective data were collected from 51 consecutive children referred for surgical treatment in Department of Paediatric Cardiac Surgery, St. Adalbertus Hospital in Gdańsk, between February and August 2015. Blood samples were collected on the first, second, and third postoperative days and sent to the institutional laboratory for routine investigations: white blood cell count, serum C-reactive protein (CRP) and procalcitonin concentrations.

Results: The highest levels of procalcitonin were on the first postoperative day (median 3.53 ng/mL), although the peak values of CRP concentration and white blood cell count were on the second postoperative day (96 mg/L and 17.3 G/L). In the group of patients with foreign material implantation (Contegra® or Gore-Tex®), the higher values of procalcitonin concentration and white blood cell count were measured in the subsequent postoperative days.

Conclusions: The kinetics of analysed inflammatory biomarkers on the first days after cardiac surgery for congenital heart disease in children have different characteristics. The knowledge about the kinetics of inflammatory biomarkers could be useful in determining the possibility of evolving infections in the early postoperative period.

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Keywords

procalcitonin, congenital heart defects, paediatric cardiac surgery, postoperative care, infections, diagnostics

About this article
Title

Postoperative kinetics of common inflammatory biomarkers after congenital heart defect procedures with extracorporeal circulation in children

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 76, No 6 (2018)

Pages

968-973

Published online

2018-01-26

DOI

10.5603/KP.a2018.0038

Bibliographic record

Kardiol Pol 2018;76(6):968-973.

Keywords

procalcitonin
congenital heart defects
paediatric cardiac surgery
postoperative care
infections
diagnostics

Authors

Ireneusz Haponiuk
Radosław Jaworski
Konrad Paczkowski
Maciej Chojnicki
Mariusz Steffens
Aneta Szofer-Sendrowska
Katarzyna Gierat-Haponiuk
Ewelina Kwaśniak
Marta Paśko-Majewska
Katarzyna Leszczyńska
Jacek Zieliński
Wiktor Szymanowicz

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