open access

Vol 75, No 12 (2017)
Original articles
Published online: 2017-07-17
Submitted: 2017-03-05
Accepted: 2017-07-06
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Hypertension, dyslipidaemia, and cardiovascular risk in HIV-infected adults in Poland

Magdalena Rogalska-Płońska, Paweł Rogalski, Magdalena Leszczyszyn-Pynka, Justyna Stempkowska, Piotr Kocbach, Aldona Kowalczuk-Kot, Małgorzata Janczarek, Anna Grzeszczuk
DOI: 10.5603/KP.a2017.0148
·
Kardiol Pol 2017;75(12):1324-1331.

open access

Vol 75, No 12 (2017)
Original articles
Published online: 2017-07-17
Submitted: 2017-03-05
Accepted: 2017-07-06

Abstract

Background: The prevalence of cardiovascular diseases (CVD) in HIV-infected patients increases with aging and duration of the disease. Hypertension, high cholesterol level obesity, diabetes, tobacco exposure, and use of alcohol are among the traditional risk factors that contribute to CVD. Aim: The aim of the study was to determinate the incidence of hypertension, lipid disturbances, and CVD risk in dependence on clinical, viral, and biochemical factors. Methods: A total of 417 HIV-infected Caucasian adult patients from the four clinical centres in Poland were enrolled and analysed on the basis of available medical data from the years 2013–2015. Results: Hypertension was diagnosed in 28% of all patients and in the age ranges: < 40 years, 41–60 years and > 60 years in 18%, 43%, and 53%, respectively. The percentage of optimal, normal, and high normal blood pressure was: 28%, 14%, and 30%, respectively. Hypertension grade 1, 2, and 3 was observed in 58%, 35%, and 7% of patients, respectively. Factors associated with hypertension were: increasing age, male sex, increased body mass index, hypercholesterolaemia, hypo-high density lipoprotein (HDL), hypertriglyceridaemia and duration of HIV infection more than 10 years. Hypercholesterolaemia, suboptimal level of HDL, elevated low-density lipoprotein, and hypertriglyceridaemia were observed in 37%, 20.5%, 31%, and 52%, respectively. Hypertriglyceridaemia was associated with protease inhibitor-based highly active antiretroviral therapy. HCV infection was negatively associated with hypercholesterolaemia. Cigarette smoking was reported in 55% of cases. Conclusions: Incidence of hypertension in particular age groups of HIV infected people is higher than in the general Polish population. Hypertension is influenced by traditional risk factors and duration of HIV infection but not antiretroviral treatment. HIV/HCV coinfection appears to be protective against hypercholesterolaemia.

Abstract

Background: The prevalence of cardiovascular diseases (CVD) in HIV-infected patients increases with aging and duration of the disease. Hypertension, high cholesterol level obesity, diabetes, tobacco exposure, and use of alcohol are among the traditional risk factors that contribute to CVD. Aim: The aim of the study was to determinate the incidence of hypertension, lipid disturbances, and CVD risk in dependence on clinical, viral, and biochemical factors. Methods: A total of 417 HIV-infected Caucasian adult patients from the four clinical centres in Poland were enrolled and analysed on the basis of available medical data from the years 2013–2015. Results: Hypertension was diagnosed in 28% of all patients and in the age ranges: < 40 years, 41–60 years and > 60 years in 18%, 43%, and 53%, respectively. The percentage of optimal, normal, and high normal blood pressure was: 28%, 14%, and 30%, respectively. Hypertension grade 1, 2, and 3 was observed in 58%, 35%, and 7% of patients, respectively. Factors associated with hypertension were: increasing age, male sex, increased body mass index, hypercholesterolaemia, hypo-high density lipoprotein (HDL), hypertriglyceridaemia and duration of HIV infection more than 10 years. Hypercholesterolaemia, suboptimal level of HDL, elevated low-density lipoprotein, and hypertriglyceridaemia were observed in 37%, 20.5%, 31%, and 52%, respectively. Hypertriglyceridaemia was associated with protease inhibitor-based highly active antiretroviral therapy. HCV infection was negatively associated with hypercholesterolaemia. Cigarette smoking was reported in 55% of cases. Conclusions: Incidence of hypertension in particular age groups of HIV infected people is higher than in the general Polish population. Hypertension is influenced by traditional risk factors and duration of HIV infection but not antiretroviral treatment. HIV/HCV coinfection appears to be protective against hypercholesterolaemia.
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Keywords

HIV, HCV, hypertension, dyslipidaemia, cardiovascular disease

About this article
Title

Hypertension, dyslipidaemia, and cardiovascular risk in HIV-infected adults in Poland

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 75, No 12 (2017)

Pages

1324-1331

Published online

2017-07-17

DOI

10.5603/KP.a2017.0148

Bibliographic record

Kardiol Pol 2017;75(12):1324-1331.

Keywords

HIV
HCV
hypertension
dyslipidaemia
cardiovascular disease

Authors

Magdalena Rogalska-Płońska
Paweł Rogalski
Magdalena Leszczyszyn-Pynka
Justyna Stempkowska
Piotr Kocbach
Aldona Kowalczuk-Kot
Małgorzata Janczarek
Anna Grzeszczuk

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