open access

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Original articles
Published online: 2017-07-17
Submitted: 2017-03-05
Accepted: 2017-07-06
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Hypertension, dyslipidemia and cardiovascular risk in HIV infected adults in Poland

Magdalena Rogalska-Płońska, Paweł Rogalski, Magdalena Leszczyszyn-Pynka, Justyna Stempkowska, Piotr Kocbach, Aldona Kowalczuk-Kot, Małgorzata Janczarek, Anna Grzeszczuk
DOI: 10.5603/KP.a2017.0148

open access

Ahead of print
Original articles
Published online: 2017-07-17
Submitted: 2017-03-05
Accepted: 2017-07-06

Abstract

Background: Prevalence of cardiovascular diseases (CVD) in HIV infected patients increases with  aging and duration of the disease. Hypertension (HA), high cholesterol level obesity, diabetes, tobacco exposure and use of alcohol are among the traditional risk factors that contribute to CVD.

Aim: was to determinate the incidence of HA, lipid disturbances and CVD risk in dependence on clinical, viral and biochemical factors.

Methods: Four hundred and seventeen HIV infected Caucasian adult patients from the four clinical centers in Poland were enrolled and analyzed on the basis of available medical data from the years 2013-2015.

Results: HA was diagnosed in 28% of all patients and in age ranges: < 40, between 41-60 and > 60 in 18%, 43% and 53% respectively. Percentage of optimal, normal and high normal blood pressure was: 28%, 14% and 30% respectively. Hypertension grade I, II and III  was observed in 58%, 35% and 7% of patients, respectively. Factors associated with HA were: increasing age, male sex, increased BMI, hypercholesterolemia, hypo-HDL, hypertriglyceridemia and duration of HIV infection more than 10 years. Hypercholesterolemia, suboptimal level of HDL, elevated LDL and hypertriglyceridemia were observed in 37%, 20.5%, 31% and 52% respectively. Hypertriglyceridemia was associated with protease inhibitors based highly active antiretroviral therapy. HCV infection was negatively associated with hypercholesterolemia. Cigarette smoking was reported in 55% of cases.

Conclusions: Incidence of HA in particular age groups of HIV infected people is higher than in general Polish population. Hypertension is influenced by traditional risk factors and duration of HIV infection but not antiretroviral treatment. HIV/HCV coinfection appears to be protective against hypercholesterolemia.

Abstract

Background: Prevalence of cardiovascular diseases (CVD) in HIV infected patients increases with  aging and duration of the disease. Hypertension (HA), high cholesterol level obesity, diabetes, tobacco exposure and use of alcohol are among the traditional risk factors that contribute to CVD.

Aim: was to determinate the incidence of HA, lipid disturbances and CVD risk in dependence on clinical, viral and biochemical factors.

Methods: Four hundred and seventeen HIV infected Caucasian adult patients from the four clinical centers in Poland were enrolled and analyzed on the basis of available medical data from the years 2013-2015.

Results: HA was diagnosed in 28% of all patients and in age ranges: < 40, between 41-60 and > 60 in 18%, 43% and 53% respectively. Percentage of optimal, normal and high normal blood pressure was: 28%, 14% and 30% respectively. Hypertension grade I, II and III  was observed in 58%, 35% and 7% of patients, respectively. Factors associated with HA were: increasing age, male sex, increased BMI, hypercholesterolemia, hypo-HDL, hypertriglyceridemia and duration of HIV infection more than 10 years. Hypercholesterolemia, suboptimal level of HDL, elevated LDL and hypertriglyceridemia were observed in 37%, 20.5%, 31% and 52% respectively. Hypertriglyceridemia was associated with protease inhibitors based highly active antiretroviral therapy. HCV infection was negatively associated with hypercholesterolemia. Cigarette smoking was reported in 55% of cases.

Conclusions: Incidence of HA in particular age groups of HIV infected people is higher than in general Polish population. Hypertension is influenced by traditional risk factors and duration of HIV infection but not antiretroviral treatment. HIV/HCV coinfection appears to be protective against hypercholesterolemia.

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Keywords

HIV, HCV, hypertension, dyslipidemia, cardiovascular disease

About this article
Title

Hypertension, dyslipidemia and cardiovascular risk in HIV infected adults in Poland

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Ahead of print

Published online

2017-07-17

DOI

10.5603/KP.a2017.0148

Keywords

HIV
HCV
hypertension
dyslipidemia
cardiovascular disease

Authors

Magdalena Rogalska-Płońska
Paweł Rogalski
Magdalena Leszczyszyn-Pynka
Justyna Stempkowska
Piotr Kocbach
Aldona Kowalczuk-Kot
Małgorzata Janczarek
Anna Grzeszczuk

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