open access

Vol 75, No 10 (2017)
Original articles
Published online: 2017-07-07
Submitted: 2016-11-06
Accepted: 2017-05-18
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Association of mean platelet volume with presence of non-viable myocardium in ischaemic cardiomyopathy

Semi Ozturk, Ahmed Seyfettin Gürbüz, Süleyman Çağan Efe, Mehmet Fatih Yılmaz, Özden Savaş Den Hartigh, Ferahnaz Çınaral Sayın, Cevat Kırma
DOI: 10.5603/KP.a2017.0136
·
Kardiol Pol 2017;75(10):1013-1019.

open access

Vol 75, No 10 (2017)
Original articles
Published online: 2017-07-07
Submitted: 2016-11-06
Accepted: 2017-05-18

Abstract

Background: Parameters derived from complete blood count, such as mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), have recently been proposed as measures of inflammation in addition to C-reactive protein (CRP), a classical inflammatory marker. Significant association of these parameters with atherosclerosis and complications have increasingly been reported.

Aim: The aim of the study is to evaluate the relationship between these parameters and the presence of myocardial viability assessed with positron emission tomography (PET) in patients with ischaemic cardiomyopathy (ICM).

Methods: A total of 122 ICM patients who had undergone PET were enrolled in this study. The patients were dichotomised depending on the presence of transmural scar. Group 1 consisted of 21 patients who had transmural scar tissue only, who were accepted as the group having non-viable myocardium. Group 2 consisted of 101 patients who had hibernation and/or non-transmural scar, who were accepted as the group having viable myocardium. Haematological parameters within 30 days of PET imaging were retrospectively analysed.

Results: There were no significant differences between the two groups regarding values of white blood cell, neutrophil, lymphocyte, platelet, haemoglobin, red cell distribution width, CRP, PLR, and NLR. Patients with non-viable myocardium have significantly higher levels of MPV (p = 0.002). In multiple logistic regression analysis, MPV (odds ratio [OR] = 0.373, 95% confidence interval [CI] 0.20–0.69, p = 0.002), was identified as an independent predictor of non-viable myocardium. In receiver-operator characteristic (ROC) analysis, a cut-point of 8.19 identified patients with non-viable myocardium (area under curve: 0.72, 95% CI 0.60–0.84). An MPV value greater than 8.19 demonstrated a sensitivity of 76% and a specificity of 55%. \

Conclusions: The present study showed that MPV is an inexpensive, clinical, and routinely measurable parameter that is associated with the presence of viable myocardium in ICM.  

Abstract

Background: Parameters derived from complete blood count, such as mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), have recently been proposed as measures of inflammation in addition to C-reactive protein (CRP), a classical inflammatory marker. Significant association of these parameters with atherosclerosis and complications have increasingly been reported.

Aim: The aim of the study is to evaluate the relationship between these parameters and the presence of myocardial viability assessed with positron emission tomography (PET) in patients with ischaemic cardiomyopathy (ICM).

Methods: A total of 122 ICM patients who had undergone PET were enrolled in this study. The patients were dichotomised depending on the presence of transmural scar. Group 1 consisted of 21 patients who had transmural scar tissue only, who were accepted as the group having non-viable myocardium. Group 2 consisted of 101 patients who had hibernation and/or non-transmural scar, who were accepted as the group having viable myocardium. Haematological parameters within 30 days of PET imaging were retrospectively analysed.

Results: There were no significant differences between the two groups regarding values of white blood cell, neutrophil, lymphocyte, platelet, haemoglobin, red cell distribution width, CRP, PLR, and NLR. Patients with non-viable myocardium have significantly higher levels of MPV (p = 0.002). In multiple logistic regression analysis, MPV (odds ratio [OR] = 0.373, 95% confidence interval [CI] 0.20–0.69, p = 0.002), was identified as an independent predictor of non-viable myocardium. In receiver-operator characteristic (ROC) analysis, a cut-point of 8.19 identified patients with non-viable myocardium (area under curve: 0.72, 95% CI 0.60–0.84). An MPV value greater than 8.19 demonstrated a sensitivity of 76% and a specificity of 55%. \

Conclusions: The present study showed that MPV is an inexpensive, clinical, and routinely measurable parameter that is associated with the presence of viable myocardium in ICM.  

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Keywords

platelet, positron emission tomography, cardiomyopathy

About this article
Title

Association of mean platelet volume with presence of non-viable myocardium in ischaemic cardiomyopathy

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 75, No 10 (2017)

Pages

1013-1019

Published online

2017-07-07

DOI

10.5603/KP.a2017.0136

Bibliographic record

Kardiol Pol 2017;75(10):1013-1019.

Keywords

platelet
positron emission tomography
cardiomyopathy

Authors

Semi Ozturk
Ahmed Seyfettin Gürbüz
Süleyman Çağan Efe
Mehmet Fatih Yılmaz
Özden Savaş Den Hartigh
Ferahnaz Çınaral Sayın
Cevat Kırma

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