open access

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Original articles
Published online: 2017-07-07
Submitted: 2016-11-06
Accepted: 2017-05-18
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Association of mean platelet volume with presence of non viable myocardium in ischemic cardiomyopathy

Semi Ozturk, Ahmed Seyfettin Gürbüz, Süleyman Çağan Efe, Mehmet Fatih Yılmaz, Özden Savaş Den Hartigh, Ferahnaz Çınaral Sayın, Cevat Kırma
DOI: 10.5603/KP.a2017.0136

open access

Ahead of print
Original articles
Published online: 2017-07-07
Submitted: 2016-11-06
Accepted: 2017-05-18

Abstract

Background and aims: Parameters derived from complete blood count such as mean platelet volume (MPV), neutrophil to lymphocyte (NLR), platelet to lymphocyte (PLR) are recently proposed as measures of inflammation in addition to C-reactive protein (CRP), a classical inflammatory marker. Significant association of these parameters with atherosclerosis and complications have increasingly been reported. Our aim is to evaluate relationship between these parameters and presence of myocardial viability  assessed with positron emission tomography (PET) in patients with ischemic cardiomyopathy.

Methods: A total of 122 ischemic cardiomyopathy patients who had undergone PET were enrolled in this study. The patients were dichotomized depending on the presence of transmural scar. Group 1 consisted of 21 patients who had transmural scar tissue, only, which were accepted as the group having non-viable myocardium. Group 2 consisted of 101 patients who had hibernation and/or non-transmural scar which were accepted as the group having viable myocardium. Hematological parameters within 30 days of PET imaging were retrospectively analyzed.

Results: There were no significant differences between two groups regarding values of WBC, neutrophil, lymphocyte, platelet, hemoglobin, RDW, CRP, PLR and NLR. Patients with non viable myocardium have significantly higher levels of MPV (p:0,002). In multiple logistic regression analysis, MPV [odds ratio (OR)=0,373, 95% confidence interval (CI) 0.20-0.69, p=0.002], was identified as independent predictor of non viable myocardium. In ROC analysis, a cut-point of 8,19 identified patients with non viable myocardium (area under curve=0.72, 95% CI 0.60-0.84). MPV value of greater than 8,19 demonstrated a sensitivity of 76%, a specificity of 55%.

Conclusions: The present study showed that MPV is an inexpensive, clinical and routinely measurable parameter that is associated with the presence of viable myocardium in ischemic cardiomyopathy.

Abstract

Background and aims: Parameters derived from complete blood count such as mean platelet volume (MPV), neutrophil to lymphocyte (NLR), platelet to lymphocyte (PLR) are recently proposed as measures of inflammation in addition to C-reactive protein (CRP), a classical inflammatory marker. Significant association of these parameters with atherosclerosis and complications have increasingly been reported. Our aim is to evaluate relationship between these parameters and presence of myocardial viability  assessed with positron emission tomography (PET) in patients with ischemic cardiomyopathy.

Methods: A total of 122 ischemic cardiomyopathy patients who had undergone PET were enrolled in this study. The patients were dichotomized depending on the presence of transmural scar. Group 1 consisted of 21 patients who had transmural scar tissue, only, which were accepted as the group having non-viable myocardium. Group 2 consisted of 101 patients who had hibernation and/or non-transmural scar which were accepted as the group having viable myocardium. Hematological parameters within 30 days of PET imaging were retrospectively analyzed.

Results: There were no significant differences between two groups regarding values of WBC, neutrophil, lymphocyte, platelet, hemoglobin, RDW, CRP, PLR and NLR. Patients with non viable myocardium have significantly higher levels of MPV (p:0,002). In multiple logistic regression analysis, MPV [odds ratio (OR)=0,373, 95% confidence interval (CI) 0.20-0.69, p=0.002], was identified as independent predictor of non viable myocardium. In ROC analysis, a cut-point of 8,19 identified patients with non viable myocardium (area under curve=0.72, 95% CI 0.60-0.84). MPV value of greater than 8,19 demonstrated a sensitivity of 76%, a specificity of 55%.

Conclusions: The present study showed that MPV is an inexpensive, clinical and routinely measurable parameter that is associated with the presence of viable myocardium in ischemic cardiomyopathy.

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Keywords

platelet, positron emission tomography, cardiomyopathy

About this article
Title

Association of mean platelet volume with presence of non viable myocardium in ischemic cardiomyopathy

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Ahead of print

Published online

2017-07-07

DOI

10.5603/KP.a2017.0136

Keywords

platelet
positron emission tomography
cardiomyopathy

Authors

Semi Ozturk
Ahmed Seyfettin Gürbüz
Süleyman Çağan Efe
Mehmet Fatih Yılmaz
Özden Savaş Den Hartigh
Ferahnaz Çınaral Sayın
Cevat Kırma

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