open access

Vol 75, No 10 (2017)
Original articles
Published online: 2017-07-07
Submitted: 2016-10-17
Accepted: 2017-05-11
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Platelet distribution width and plateletcrit: novel biomarkers of ST elevation myocardial infarction in young patients

Mehmet Serkan Cetin, Elif Hande Ozcan Cetin, Ahmet Akdi, Dursun Aras, Serkan Topaloglu, Ahmet Temizhan, Sinan Aydogdu
DOI: 10.5603/KP.a2017.0135
·
Kardiol Pol 2017;75(10):1005-1012.

open access

Vol 75, No 10 (2017)
Original articles
Published online: 2017-07-07
Submitted: 2016-10-17
Accepted: 2017-05-11

Abstract

Background: Platelets play a central role in myocardial infarction, and platelet activity can be evaluated with platelet indices, including platelet distribution width (PDW) and plateletcrit (PCT). These indices have been demonstrated as markers of prothrombotic state in cardiovascular diseases.

Aim: Therefore, we aimed to investigate, the usefulness of these biomarkers in ST-elevation myocardial infarction (STEMI) in young patients.

Methods: This cross-sectional study consisted of 565 subjects who were classified into three groups: group 1 (168 young patients with STEMI), group 2 (173 non-young patients with STEMI), and group 3 (224 age-matched controls with angiographically normal coronary arteries). Male patients aged under 45 years and female patients aged under 55 years were defined as young STEMI.

Results: In group 1, PDW and PCT (17.2 ± 0.67, 0.249 ± 0.05, respectively) were significantly higher than the other groups (group 2, 16.4 ± 0.56, 0.231 ± 0.04; group 3, 15.1 ± 0.63, 0.227 ± 0.04). PDW and PCT had moderate negative correlation (r = –0.305, r = –0.330, respectively) with age and moderate positive correlation with peak creatine kinase MB (r = 0.259, r = 0.320, respectively). At multivariate analysis, adjusted for other factors, 1 fL increase in PDW levels was 13.5% more likely to be associated with young STEMI, and similarly, a 1% increase in PCT levels was 18.9% more likely associated with young STEMI.

Conclusions: Platelet distribution width and plateletcrit levels seem to be independent markers of STEMI in young patients and may reflect prothrombotic state in this specific population.

Abstract

Background: Platelets play a central role in myocardial infarction, and platelet activity can be evaluated with platelet indices, including platelet distribution width (PDW) and plateletcrit (PCT). These indices have been demonstrated as markers of prothrombotic state in cardiovascular diseases.

Aim: Therefore, we aimed to investigate, the usefulness of these biomarkers in ST-elevation myocardial infarction (STEMI) in young patients.

Methods: This cross-sectional study consisted of 565 subjects who were classified into three groups: group 1 (168 young patients with STEMI), group 2 (173 non-young patients with STEMI), and group 3 (224 age-matched controls with angiographically normal coronary arteries). Male patients aged under 45 years and female patients aged under 55 years were defined as young STEMI.

Results: In group 1, PDW and PCT (17.2 ± 0.67, 0.249 ± 0.05, respectively) were significantly higher than the other groups (group 2, 16.4 ± 0.56, 0.231 ± 0.04; group 3, 15.1 ± 0.63, 0.227 ± 0.04). PDW and PCT had moderate negative correlation (r = –0.305, r = –0.330, respectively) with age and moderate positive correlation with peak creatine kinase MB (r = 0.259, r = 0.320, respectively). At multivariate analysis, adjusted for other factors, 1 fL increase in PDW levels was 13.5% more likely to be associated with young STEMI, and similarly, a 1% increase in PCT levels was 18.9% more likely associated with young STEMI.

Conclusions: Platelet distribution width and plateletcrit levels seem to be independent markers of STEMI in young patients and may reflect prothrombotic state in this specific population.

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Keywords

plateletcrit, platelet distribution width, ST elevation myocardial infarction, young patients

About this article
Title

Platelet distribution width and plateletcrit: novel biomarkers of ST elevation myocardial infarction in young patients

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 75, No 10 (2017)

Pages

1005-1012

Published online

2017-07-07

DOI

10.5603/KP.a2017.0135

Bibliographic record

Kardiol Pol 2017;75(10):1005-1012.

Keywords

plateletcrit
platelet distribution width
ST elevation myocardial infarction
young patients

Authors

Mehmet Serkan Cetin
Elif Hande Ozcan Cetin
Ahmet Akdi
Dursun Aras
Serkan Topaloglu
Ahmet Temizhan
Sinan Aydogdu

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