open access

Ahead of print
Original articles
Published online: 2017-07-07
Submitted: 2016-10-17
Accepted: 2017-05-11
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Platelet distribution width and plateletcrit: novel biomarkers of ST elevation myocardial infarction in young patients

Mehmet Serkan Çetin, Elif Hande Özcan Çetin, Ahmet Akdi, Dursun Aras, Serkan Topaloğlu, Ahmet Temizhan, Sinan Aydoğdu
DOI: 10.5603/KP.a2017.0135

open access

Ahead of print
Original articles
Published online: 2017-07-07
Submitted: 2016-10-17
Accepted: 2017-05-11

Abstract

Background: Platelets play a central role in myocardial infarction, and platelet activity can be evaluated with platelet indices including, platelet distribution width (PDW) and plateletcrit (PCT). These indices have been demonstrated as markers of prothrombotic state in cardiovascular diseases. Therefore, we aimed to investigate, the usefulness of these biomarkers in ST-elevation myocardial infarction (STEMI) in young patients. 

Methods: This cross-sectional study consisted 565 subjects which classified into three groups: group 1 (168 young patients with STEMI), group 2 (173 non-young patients with STEMI), and group 3 (224 age-matched controls with angiographically normal coronary arteries). Male patients aged under 45 years and females patients aged under 55 years were defined as young STEMI.

Results: In Group 1, PDW and PCT (17.2±0.67, 0.249±0.05 respectively) were significantly higher than the other groups (Group 2, 16.4±0.56, 0.231±0.04; Group 3, 15.1±0.63, 0.227±0.04 respectively). PDW and PCT had moderate negative correlation (r=-0.305, r=-0.330 respectively) with age and moderate positive correlation with peak CK-MB (r=0.259, r=0.320 respectively). At multivariate analysis, adjusted for other factors, one fL increase in PDW levels was 13.5% more likely associated with young STEMI, and similarly, one percent increase in PCT levels was 18.9% more likely associated with young STEMI. 

Conclusions: PDW and PCT levels seem to be independent markers of STEMI in young patients and may reflect prothrombotic state in this specific population.

Abstract

Background: Platelets play a central role in myocardial infarction, and platelet activity can be evaluated with platelet indices including, platelet distribution width (PDW) and plateletcrit (PCT). These indices have been demonstrated as markers of prothrombotic state in cardiovascular diseases. Therefore, we aimed to investigate, the usefulness of these biomarkers in ST-elevation myocardial infarction (STEMI) in young patients. 

Methods: This cross-sectional study consisted 565 subjects which classified into three groups: group 1 (168 young patients with STEMI), group 2 (173 non-young patients with STEMI), and group 3 (224 age-matched controls with angiographically normal coronary arteries). Male patients aged under 45 years and females patients aged under 55 years were defined as young STEMI.

Results: In Group 1, PDW and PCT (17.2±0.67, 0.249±0.05 respectively) were significantly higher than the other groups (Group 2, 16.4±0.56, 0.231±0.04; Group 3, 15.1±0.63, 0.227±0.04 respectively). PDW and PCT had moderate negative correlation (r=-0.305, r=-0.330 respectively) with age and moderate positive correlation with peak CK-MB (r=0.259, r=0.320 respectively). At multivariate analysis, adjusted for other factors, one fL increase in PDW levels was 13.5% more likely associated with young STEMI, and similarly, one percent increase in PCT levels was 18.9% more likely associated with young STEMI. 

Conclusions: PDW and PCT levels seem to be independent markers of STEMI in young patients and may reflect prothrombotic state in this specific population.

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Keywords

plateletcrit, platelet distribution width, ST elevation myocardial infarction, young patients

About this article
Title

Platelet distribution width and plateletcrit: novel biomarkers of ST elevation myocardial infarction in young patients

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Ahead of print

Published online

2017-07-07

DOI

10.5603/KP.a2017.0135

Keywords

plateletcrit
platelet distribution width
ST elevation myocardial infarction
young patients

Authors

Mehmet Serkan Çetin
Elif Hande Özcan Çetin
Ahmet Akdi
Dursun Aras
Serkan Topaloğlu
Ahmet Temizhan
Sinan Aydoğdu

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