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Published online: 2017-06-28
Submitted: 2017-01-06
Accepted: 2017-05-25
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Increased plasma asymmetric dimethylarginine level is associated with ascending aorta dilatation: a case-control study

Muhammet Hulusi Satılmışoğlu, Vesile Örnek Diker, Ömer Taşbulak, Mustafa Diker, Ali Birand, Mehmet Kaya, Taner İyigün, Abdurrahman Eksik
DOI: 10.5603/KP.a2017.0123

open access

Ahead of print
Original articles
Published online: 2017-06-28
Submitted: 2017-01-06
Accepted: 2017-05-25

Abstract

Background: Asymetric dimethyl arginin (ADMA) is an endogenous inhibitor of nitric oxide synthase.

Aim: We aimed to determine plasma ADMA level in patients with ascending aorta dilatation in comparison to those without aorta dilatation and to evaluate the diagnostic, predictive and prognostic value of serum ADMA level for aorta dilatation.

Methods: This was a cross-sectional case-control study. One hundred-four consecutive patients (female/male, 35/69; mean age, 62.75±13.11 years) diagnosed with ascending aorta dilatation (≥4.5 cm) on echocardiography (case group), and 52 age- and gender-matched patients (female/male, 17/35; mean age, 63.44±7.56 years) with normal aorta dimensions (≤3.8 cm) (control group) were included. Routine biochemical and hematological analysis in addition to measurement of serum ADMA level were performed.

Results: The mean diameter of ascending aorta measured on echocardiography was 4.95±0.57 cm and 3.34±0.36 cm in patients with aorta dilatation and those without aorta dilatation, respectively (p<0.001). Serum ADMA level was significantly higher in patients with aorta dilatation than control group (1.70±1.12 µmol/L vs. 0.79±0.76 µmol/L, respectively, p<0.001). There was significant positive correlation between ADMA level and aortic diameter in Spearman correlation analysis (r=0.317, p<0.001). In linear regression analysis, ADMA was found to be a significant independent predictor of aorta diameter (Beta=0.26 p<0.001). ROC curve analysis also revealed that serum ADMA cut-off level over 0.29 µmol/L predicts aorta dilatation (≥4.5 cm) with 94% sensitivity and 92% specificity and with high accuracy (area under curve, 0.786; 95% confidence interval 0.709-0.863, p<0.001).

Conclusions: Serum ADMA level is diagnostic for ascending aorta dilatation with high sensitivity and specificity, thus should be considered to be used in clinical diagnosis of aorta dilatation.

Abstract

Background: Asymetric dimethyl arginin (ADMA) is an endogenous inhibitor of nitric oxide synthase.

Aim: We aimed to determine plasma ADMA level in patients with ascending aorta dilatation in comparison to those without aorta dilatation and to evaluate the diagnostic, predictive and prognostic value of serum ADMA level for aorta dilatation.

Methods: This was a cross-sectional case-control study. One hundred-four consecutive patients (female/male, 35/69; mean age, 62.75±13.11 years) diagnosed with ascending aorta dilatation (≥4.5 cm) on echocardiography (case group), and 52 age- and gender-matched patients (female/male, 17/35; mean age, 63.44±7.56 years) with normal aorta dimensions (≤3.8 cm) (control group) were included. Routine biochemical and hematological analysis in addition to measurement of serum ADMA level were performed.

Results: The mean diameter of ascending aorta measured on echocardiography was 4.95±0.57 cm and 3.34±0.36 cm in patients with aorta dilatation and those without aorta dilatation, respectively (p<0.001). Serum ADMA level was significantly higher in patients with aorta dilatation than control group (1.70±1.12 µmol/L vs. 0.79±0.76 µmol/L, respectively, p<0.001). There was significant positive correlation between ADMA level and aortic diameter in Spearman correlation analysis (r=0.317, p<0.001). In linear regression analysis, ADMA was found to be a significant independent predictor of aorta diameter (Beta=0.26 p<0.001). ROC curve analysis also revealed that serum ADMA cut-off level over 0.29 µmol/L predicts aorta dilatation (≥4.5 cm) with 94% sensitivity and 92% specificity and with high accuracy (area under curve, 0.786; 95% confidence interval 0.709-0.863, p<0.001).

Conclusions: Serum ADMA level is diagnostic for ascending aorta dilatation with high sensitivity and specificity, thus should be considered to be used in clinical diagnosis of aorta dilatation.

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Keywords

aorta dilatation, asymetric dimethyl arginin, biomarker, diagnosis

About this article
Title

Increased plasma asymmetric dimethylarginine level is associated with ascending aorta dilatation: a case-control study

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Ahead of print

Published online

2017-06-28

DOI

10.5603/KP.a2017.0123

Keywords

aorta dilatation
asymetric dimethyl arginin
biomarker
diagnosis

Authors

Muhammet Hulusi Satılmışoğlu
Vesile Örnek Diker
Ömer Taşbulak
Mustafa Diker
Ali Birand
Mehmet Kaya
Taner İyigün
Abdurrahman Eksik

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