open access

Ahead of print
Original articles
Published online: 2017-06-01
Submitted: 2016-12-22
Accepted: 2017-05-18
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Association of Serglycin levels with Isolated Coronary Artery Ectasia

Harun Kundi, Murat Gok, Canan Topcuoglu, Ender Ornek
DOI: 10.5603/KP.a2017.0119

open access

Ahead of print
Original articles
Published online: 2017-06-01
Submitted: 2016-12-22
Accepted: 2017-05-18

Abstract

Background: Serglycin has an important role in the inflammatory status and the relationship between coronary artery ectasia (CAE) and serglycin is still unknown.

Aim: In this study, we aimed to investigate association of serglycin level with isolated CAE.

Methods: Fifty-two patients with isolated CAE and 35 individuals with normal coronary angiography were included into the study. Markis classification and number of ectatic coronary arteries were recorded. Plasma serglycin levels were measured.

Results: Multivariate logistic regression analysis revealed that serglycin and high-sensitivity C-reactive protein were independently associated with the presence of CAE. In receiver operating characteristics curve analysis the cut of serglycin level for the prediction isolated CAE was 13.5 with a sensitivity of 88.5% and a specificity of 84.8%. However, there was no association between serglycin levels and Markis classification.

Conclusions: Serglycin level is significantly and independently higher in patients with CAE.

Abstract

Background: Serglycin has an important role in the inflammatory status and the relationship between coronary artery ectasia (CAE) and serglycin is still unknown.

Aim: In this study, we aimed to investigate association of serglycin level with isolated CAE.

Methods: Fifty-two patients with isolated CAE and 35 individuals with normal coronary angiography were included into the study. Markis classification and number of ectatic coronary arteries were recorded. Plasma serglycin levels were measured.

Results: Multivariate logistic regression analysis revealed that serglycin and high-sensitivity C-reactive protein were independently associated with the presence of CAE. In receiver operating characteristics curve analysis the cut of serglycin level for the prediction isolated CAE was 13.5 with a sensitivity of 88.5% and a specificity of 84.8%. However, there was no association between serglycin levels and Markis classification.

Conclusions: Serglycin level is significantly and independently higher in patients with CAE.

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Keywords

coronary artery ectasia; inflammation; serglycin

About this article
Title

Association of Serglycin levels with Isolated Coronary Artery Ectasia

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Ahead of print

Published online

2017-06-01

DOI

10.5603/KP.a2017.0119

Keywords

coronary artery ectasia
inflammation
serglycin

Authors

Harun Kundi
Murat Gok
Canan Topcuoglu
Ender Ornek

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