open access

Vol 76, No 5 (2018)
Original articles
Published online: 2018-01-06
Submitted: 2017-09-24
Accepted: 2017-12-18
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The relationship between post-procedural platelet count and left ventricular aneurysm in patients with acute anterior ST-segment elevation myocardial infarction following primary percutaneous coronary intervention

Zuoyan Wang, Lihui Ren, Na Liu, Jianjun Peng
DOI: 10.5603/KP.2018.0008
·
Kardiol Pol 2018;76(5):899-907.

open access

Vol 76, No 5 (2018)
Original articles
Published online: 2018-01-06
Submitted: 2017-09-24
Accepted: 2017-12-18

Abstract

Background:

Left ventricular aneurysm (LVA) relates to worse prognosis in patients with myocardial infarction despite successful reperfusion treatment. There is no evidence that early detectable biomarkers can predict the risk for the future development of LVA.


Aim:

The aim of our study was to investigate the possible predictive value of periprocedural haematological parameters for LVA.


Methods:

A total of 281 patients with acute anterior ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (pPCI) were enrolled. Haematological parameters were measured on admission before pPCI and between 8 and 12 h after pPCI, separately. The development of LVA was evaluated at one-year follow-up. The patients were then divided into two groups: an LVA group and a non-LVA group. Univariate and multivariate logistic regression analyses were performed to find the predictors of LVA.


Results:

A total of 34 (12.1%) patients developed LVA at one-year follow-up after pPCI. Multivariate analyses revealed that a 10 × 109/L increase in platelet count 12 h after pPCI (odds ratio [OR] 1.092, 95% confidence interval [CI] 1.015–1.188, p = 0.039), peak cardiac troponin I (OR 1.107, 95% CI 1.003–1.215, p = 0.000), and left ventricular ejection fraction (OR 0.853, 95% CI 0.772–0.943, p = 0.002) were independent risk factors for LVA. For the prediction of LVA, platelet count 12 h after pPCI at a cut-off value > 197 × 109/L yielded a receiver operating characteristic-area under the curve (ROC-AUC) of 0.635 (82.3% sensitivity, 44.1% specificity).


Conclusions:

Platelet count after pPCI was significantly associated with the development of LVA in anterior STEMI patients and may be available for early risk stratification of future LVA formation.

Abstract

Background:

Left ventricular aneurysm (LVA) relates to worse prognosis in patients with myocardial infarction despite successful reperfusion treatment. There is no evidence that early detectable biomarkers can predict the risk for the future development of LVA.


Aim:

The aim of our study was to investigate the possible predictive value of periprocedural haematological parameters for LVA.


Methods:

A total of 281 patients with acute anterior ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (pPCI) were enrolled. Haematological parameters were measured on admission before pPCI and between 8 and 12 h after pPCI, separately. The development of LVA was evaluated at one-year follow-up. The patients were then divided into two groups: an LVA group and a non-LVA group. Univariate and multivariate logistic regression analyses were performed to find the predictors of LVA.


Results:

A total of 34 (12.1%) patients developed LVA at one-year follow-up after pPCI. Multivariate analyses revealed that a 10 × 109/L increase in platelet count 12 h after pPCI (odds ratio [OR] 1.092, 95% confidence interval [CI] 1.015–1.188, p = 0.039), peak cardiac troponin I (OR 1.107, 95% CI 1.003–1.215, p = 0.000), and left ventricular ejection fraction (OR 0.853, 95% CI 0.772–0.943, p = 0.002) were independent risk factors for LVA. For the prediction of LVA, platelet count 12 h after pPCI at a cut-off value > 197 × 109/L yielded a receiver operating characteristic-area under the curve (ROC-AUC) of 0.635 (82.3% sensitivity, 44.1% specificity).


Conclusions:

Platelet count after pPCI was significantly associated with the development of LVA in anterior STEMI patients and may be available for early risk stratification of future LVA formation.

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Keywords

platelet count, left ventricular aneurysm, primary percutaneous coronary intervention, ST-segment elevation myocardial infarction

About this article
Title

The relationship between post-procedural platelet count and left ventricular aneurysm in patients with acute anterior ST-segment elevation myocardial infarction following primary percutaneous coronary intervention

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 76, No 5 (2018)

Pages

899-907

Published online

2018-01-06

DOI

10.5603/KP.2018.0008

Bibliographic record

Kardiol Pol 2018;76(5):899-907.

Keywords

platelet count
left ventricular aneurysm
primary percutaneous coronary intervention
ST-segment elevation myocardial infarction

Authors

Zuoyan Wang
Lihui Ren
Na Liu
Jianjun Peng

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