open access

Vol 71, No 11 (2013)
Original articles
Published online: 2013-11-18
Submitted: 2013-05-02
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The relationship between platelet indices and clinical features of coronary artery disease

Ugur Turk, Istemihan Tengiz, Emre Ozpelit, Aydan Celebiler, Nihat Pekel, Ferhat Ozyurtlu, Emin Alioglu, Ertugrul Ercan
DOI: 10.5603/KP.2013.0293
·
Kardiol Pol 2013;71(11):1129-1134.

open access

Vol 71, No 11 (2013)
Original articles
Published online: 2013-11-18
Submitted: 2013-05-02

Abstract

Background: Platelets play a key role in the development and progression of cardiovascular disease. The degree of platelet activation may be assessed by platelet indices such as platelet count, mean platelet volume (MPV) and platelet distribution width (PDW).

Aim: To evaluate the relationship between platelet indices and clinical features of coronary artery disease (CAD).

Methods: Our population is represented by a total of 441 consecutive patients undergoing coronary angiography. Patients were divided into three groups according to their clinical presentation: Patients with stable angina (Group I), with acute coronary syndrome (Group II), and with a normal coronary angiogram (Group III). All demographic and clinical features were collected retrospectively. Platelet indices were measured in all patients.

Results: There was no statistical difference for platelet count, MPV and PDW values among the groups. Correlation analysis showed a positive association between platelet count and Gensini scoring (Kendall’s tau b, r = 0.312, p = 0.037, two-tailed)and also age (Kendall’s tau b, r = 0.518, p = 0.001, two-tailed) in patients with CAD. However, there was no significant correlation between Gensini scoring and MPV or PDW values in these patients.

Conclusions: PDW and MPV may not be related to the clinical features or presentation and extent of CAD. Our study findings add to the conflicting results of previous studies in this area. Prospective trials with longer follow-up periods and largersamples are warranted to conclusively define the role of platelet indices in CAD.

Abstract

Background: Platelets play a key role in the development and progression of cardiovascular disease. The degree of platelet activation may be assessed by platelet indices such as platelet count, mean platelet volume (MPV) and platelet distribution width (PDW).

Aim: To evaluate the relationship between platelet indices and clinical features of coronary artery disease (CAD).

Methods: Our population is represented by a total of 441 consecutive patients undergoing coronary angiography. Patients were divided into three groups according to their clinical presentation: Patients with stable angina (Group I), with acute coronary syndrome (Group II), and with a normal coronary angiogram (Group III). All demographic and clinical features were collected retrospectively. Platelet indices were measured in all patients.

Results: There was no statistical difference for platelet count, MPV and PDW values among the groups. Correlation analysis showed a positive association between platelet count and Gensini scoring (Kendall’s tau b, r = 0.312, p = 0.037, two-tailed)and also age (Kendall’s tau b, r = 0.518, p = 0.001, two-tailed) in patients with CAD. However, there was no significant correlation between Gensini scoring and MPV or PDW values in these patients.

Conclusions: PDW and MPV may not be related to the clinical features or presentation and extent of CAD. Our study findings add to the conflicting results of previous studies in this area. Prospective trials with longer follow-up periods and largersamples are warranted to conclusively define the role of platelet indices in CAD.

Get Citation

Keywords

platelet indices, mean platelet volume, platelet distribution

About this article
Title

The relationship between platelet indices and clinical features of coronary artery disease

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 71, No 11 (2013)

Pages

1129-1134

Published online

2013-11-18

DOI

10.5603/KP.2013.0293

Bibliographic record

Kardiol Pol 2013;71(11):1129-1134.

Keywords

platelet indices
mean platelet volume
platelet distribution

Authors

Ugur Turk
Istemihan Tengiz
Emre Ozpelit
Aydan Celebiler
Nihat Pekel
Ferhat Ozyurtlu
Emin Alioglu
Ertugrul Ercan

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