open access

Vol 71, No 10 (2013)
Original articles
Published online: 2013-10-16
Submitted: 2013-05-02
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Impact of levosimendan on right ventricular functions by using novel tissue Doppler derived indices in patients with ischaemic left ventricular failure

Fatma Alibaz-Oner, Ozlem Zeynep Gurbuz, Ender Oner, Selen Yurdakul, Mecdi Erguney
DOI: 10.5603/KP.2013.0258
·
Kardiol Pol 2013;71(10):1036-1041.

open access

Vol 71, No 10 (2013)
Original articles
Published online: 2013-10-16
Submitted: 2013-05-02

Abstract

Background: Right ventricular (RV) dysfunction complicates advanced left ventricular (LV) heart failure (HF) and contributes to a poor prognosis. Levosimendan is a positive inotropic agent improving cardiac contractility without increasing myocardial oxygen consumption in HF.

Aim: To evaluate the effect of levosimendan therapy on RV systolic function, by using derived tissue Doppler imaging (TDI) in patients with ischaemic HF.

Methods: The study consisted of 30 patients with HF who were admitted to our hospital due to new onset of decompensated HF, having LV ejection fraction < 40%, with functional status class III–IV, according to the New York Heart Association (NYHA). TDI-derived systolic velocities of tricuspid annulus (isovolumic myocardial acceleration [IVA], peak myocardial velocity during isovolumic contraction [IVV], peak systolic velocity during ejection period [Sa]) and diastolic indices (early [Ea] and late diastolic [Aa] velocities, Ea/Aa, E/Ea ratios and myocardial performance index [Tei index]) were measured. 72 hours after treatment, all measurements were re-evaluated.

Results: Considering TDI-derived systolic indices of the RV, IVA and IVV increased significantly, whereas Tei index decreased, after the therapy. Also, there was a significant decrease in serum levels of B-type natriuretic peptide. No significant change was observed in TDI derived diastolic indices of the RV.

Conclusıons: Levosimendan improves RV systolic function as expressed by TDI-derived parameters in patients with acutedecompensated HF.

Abstract

Background: Right ventricular (RV) dysfunction complicates advanced left ventricular (LV) heart failure (HF) and contributes to a poor prognosis. Levosimendan is a positive inotropic agent improving cardiac contractility without increasing myocardial oxygen consumption in HF.

Aim: To evaluate the effect of levosimendan therapy on RV systolic function, by using derived tissue Doppler imaging (TDI) in patients with ischaemic HF.

Methods: The study consisted of 30 patients with HF who were admitted to our hospital due to new onset of decompensated HF, having LV ejection fraction < 40%, with functional status class III–IV, according to the New York Heart Association (NYHA). TDI-derived systolic velocities of tricuspid annulus (isovolumic myocardial acceleration [IVA], peak myocardial velocity during isovolumic contraction [IVV], peak systolic velocity during ejection period [Sa]) and diastolic indices (early [Ea] and late diastolic [Aa] velocities, Ea/Aa, E/Ea ratios and myocardial performance index [Tei index]) were measured. 72 hours after treatment, all measurements were re-evaluated.

Results: Considering TDI-derived systolic indices of the RV, IVA and IVV increased significantly, whereas Tei index decreased, after the therapy. Also, there was a significant decrease in serum levels of B-type natriuretic peptide. No significant change was observed in TDI derived diastolic indices of the RV.

Conclusıons: Levosimendan improves RV systolic function as expressed by TDI-derived parameters in patients with acutedecompensated HF.

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Keywords

levosimendan, ischaemic heart failure, right ventricle, tissue Doppler imaging

About this article
Title

Impact of levosimendan on right ventricular functions by using novel tissue Doppler derived indices in patients with ischaemic left ventricular failure

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 71, No 10 (2013)

Pages

1036-1041

Published online

2013-10-16

DOI

10.5603/KP.2013.0258

Bibliographic record

Kardiol Pol 2013;71(10):1036-1041.

Keywords

levosimendan
ischaemic heart failure
right ventricle
tissue Doppler imaging

Authors

Fatma Alibaz-Oner
Ozlem Zeynep Gurbuz
Ender Oner
Selen Yurdakul
Mecdi Erguney

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