open access

Vol 70, No 6 (2012)
Original articles
Published online: 2012-06-20
Submitted: 2012-12-28
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Selected clotting factors in blood of patients with abdominal aortic aneurysms

Maria Kotschy, Wojciech Witkiewicz, Ryszard Grendziak, Joanna Dubis, Norbert Zapotoczny, Daniel Kotschy
Kardiol Pol 2012;70(6):574-579.

open access

Vol 70, No 6 (2012)
Original articles
Published online: 2012-06-20
Submitted: 2012-12-28

Abstract


Background: Tissue factor (TF), tissue factor pathway inhibitor (TFPI) and vascular endothelial growth factor A (VEGF-A) present in vascular structures take part in blood coagulation and in organ revascularisation. The concentration of thrombin–antithrombin complexes (TAT) in blood of patients with abdominal aortic aneurysms (AAA) reflects thrombin-generation.
Aim: To determine the concentration of TF, TFPI, VEGF-A and TAT complexes in blood of patients with AAA and to consider if these factors after clot formation can play a role in the pathogenesis of abdominal aortic aneurysms.
Methods: Forty eight patients (43 men and 5 women) in the age of 59–80 (mean 72) years with AAA were examined. The blood was drawn in the morning to 3.2% natrium citrate in proportion 9:1. The concentration of TF, TFPI, VEGF-A and TAT complexes were measured in plasma with commercial kits using enzyme immunoassay.
Results: In plasma of patients with AAA the mean concentration of TF was elevated almost twice and TAT complexes were three times higher compared with controls. But the mean levels of TFPI and VEGF-A were similar as in control group.
Conclusions: Increased concentrations of TF and TAT complexes indicate on high thrombin-generation, hypercoagulability and formation in abdominal aortic aneurysm of intraluminal thrombus, which can induce proteolytic processes in aortic wall.

Abstract


Background: Tissue factor (TF), tissue factor pathway inhibitor (TFPI) and vascular endothelial growth factor A (VEGF-A) present in vascular structures take part in blood coagulation and in organ revascularisation. The concentration of thrombin–antithrombin complexes (TAT) in blood of patients with abdominal aortic aneurysms (AAA) reflects thrombin-generation.
Aim: To determine the concentration of TF, TFPI, VEGF-A and TAT complexes in blood of patients with AAA and to consider if these factors after clot formation can play a role in the pathogenesis of abdominal aortic aneurysms.
Methods: Forty eight patients (43 men and 5 women) in the age of 59–80 (mean 72) years with AAA were examined. The blood was drawn in the morning to 3.2% natrium citrate in proportion 9:1. The concentration of TF, TFPI, VEGF-A and TAT complexes were measured in plasma with commercial kits using enzyme immunoassay.
Results: In plasma of patients with AAA the mean concentration of TF was elevated almost twice and TAT complexes were three times higher compared with controls. But the mean levels of TFPI and VEGF-A were similar as in control group.
Conclusions: Increased concentrations of TF and TAT complexes indicate on high thrombin-generation, hypercoagulability and formation in abdominal aortic aneurysm of intraluminal thrombus, which can induce proteolytic processes in aortic wall.
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Keywords

TF; TFPI; VEGF-A; TAT complexes; abdominal aortic aneurysms

About this article
Title

Selected clotting factors in blood of patients with abdominal aortic aneurysms

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 70, No 6 (2012)

Pages

574-579

Published online

2012-06-20

Bibliographic record

Kardiol Pol 2012;70(6):574-579.

Keywords

TF
TFPI
VEGF-A
TAT complexes
abdominal aortic aneurysms

Authors

Maria Kotschy
Wojciech Witkiewicz
Ryszard Grendziak
Joanna Dubis
Norbert Zapotoczny
Daniel Kotschy

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