open access

Vol 68, No 8 (2010)
Original articles
Published online: 2010-08-21
Submitted: 2012-12-28
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Distribution of the Trp64Arg polymorphism in the β3-adrenergic receptor gene in athletes and its influence on cardiovascular function

Sung Min Kim, Sang Duk Oh, In Geun Jung, Jin Lee, Young Je Sim, Jae Koo Lee, Byung Yong Kang
Kardiol Pol 2010;68(8):920-926.

open access

Vol 68, No 8 (2010)
Original articles
Published online: 2010-08-21
Submitted: 2012-12-28

Abstract


Background: The Trp64Arg polymorphism in the β3-adrenergic receptor (β3-AR) gene was extensively studied concerning the relationship with cardiovascular (CV) diseases, but few studies addressed this issue in athletes.
Aim: To examine the relationship between the Trp64Arg polymorphism in the β3-AR gene and several CV functions such as cardiac structure and function or blood biochemical parameters in Korean male controls and athletes.
Methods: We recruited a total of 114 study subjects, including 81 male athletes (8 long distance runners, 17 soccer, 8 baseball, 10 basketball, 8 volleyball, 8 ice hockey, 8 judo, 6 taekwondo and 8 gymnastics) and 33 controls. Two dimensional echocardiography was performed in order to assess the cardiac structure and function and blood biochemical parameters were measured. Genotyping of Trp64Arg polymorphism in the β3-AR gene was also performed by the SNaPshot method.
Results: The genotype and allele distribution of Trp64Arg polymorphism in the β3-AR gene were significantly different among each sporting discipline, showing the highest Arg allele frequency in volleyball and gymnastics (p < 0.05). Also, this polymorphism was significantly associated with serum HDL-cholesterol and glucose level in athletes only (p < 0.05).
Conclusions: Our data showed the significant associations between the Trp64Arg polymorphism in the β3-AR gene and some CV parameters such as serum HDL-cholesterol and glucose levels in athletes. However, further studies of the precise mechanism behind these associations are needed.
Kardiol Pol 2010; 68, 8: 920-926

Abstract


Background: The Trp64Arg polymorphism in the β3-adrenergic receptor (β3-AR) gene was extensively studied concerning the relationship with cardiovascular (CV) diseases, but few studies addressed this issue in athletes.
Aim: To examine the relationship between the Trp64Arg polymorphism in the β3-AR gene and several CV functions such as cardiac structure and function or blood biochemical parameters in Korean male controls and athletes.
Methods: We recruited a total of 114 study subjects, including 81 male athletes (8 long distance runners, 17 soccer, 8 baseball, 10 basketball, 8 volleyball, 8 ice hockey, 8 judo, 6 taekwondo and 8 gymnastics) and 33 controls. Two dimensional echocardiography was performed in order to assess the cardiac structure and function and blood biochemical parameters were measured. Genotyping of Trp64Arg polymorphism in the β3-AR gene was also performed by the SNaPshot method.
Results: The genotype and allele distribution of Trp64Arg polymorphism in the β3-AR gene were significantly different among each sporting discipline, showing the highest Arg allele frequency in volleyball and gymnastics (p < 0.05). Also, this polymorphism was significantly associated with serum HDL-cholesterol and glucose level in athletes only (p < 0.05).
Conclusions: Our data showed the significant associations between the Trp64Arg polymorphism in the β3-AR gene and some CV parameters such as serum HDL-cholesterol and glucose levels in athletes. However, further studies of the precise mechanism behind these associations are needed.
Kardiol Pol 2010; 68, 8: 920-926
Get Citation

Keywords

athletes; β3-adrenergic receptor and polymorphism

About this article
Title

Distribution of the Trp64Arg polymorphism in the β3-adrenergic receptor gene in athletes and its influence on cardiovascular function

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 68, No 8 (2010)

Pages

920-926

Published online

2010-08-21

Bibliographic record

Kardiol Pol 2010;68(8):920-926.

Keywords

athletes
β3-adrenergic receptor and polymorphism

Authors

Sung Min Kim
Sang Duk Oh
In Geun Jung
Jin Lee
Young Je Sim
Jae Koo Lee
Byung Yong Kang

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