open access

Vol 68, Supp. V (2010)
Reviews
Published online: 2010-11-25
Submitted: 2012-12-28
Get Citation

The role of nitric oxide, hydrogen sulfide and carbon monoxide in the regulation of the circulatory system and their pharmacotherapeutic potential

Marcin Ufnal, Tymoteusz Żera

open access

Vol 68, Supp. V (2010)
Reviews
Published online: 2010-11-25
Submitted: 2012-12-28

Abstract

In the eighties of the twentieth century nitric oxide (NO) was identified as the endothelium-derived relaxing factor. This discovery has triggered an interest in gaseous transmitters and their role in the regulation of the circulatory system. Recently, it has become evident that hydrogen sulfide (H2S) and carbon monoxide are also involved in physiological and pathological processes in the cardiovascular system. Nitrates that have been used for over a century and nebivolol, a third-generation b-blocker with vasodilating properties by increasing bioavailability of NO, provide convincing arguments that the compounds acting via NO pathway will remain an important class of cardiovascular drugs. A rapidly growing number of publications on functions of H2S in the circulatory system suggests that the gaseous transmitter may become a promising target for new treatment strategies in cardiovascular diseases. This review is focused on the role of gaseous transmitters in the regulation of the cardiovascular system and their pharmacotherapeutic potential.
Kardiol Pol 2010; 68, supl. V: 436-440

Abstract

In the eighties of the twentieth century nitric oxide (NO) was identified as the endothelium-derived relaxing factor. This discovery has triggered an interest in gaseous transmitters and their role in the regulation of the circulatory system. Recently, it has become evident that hydrogen sulfide (H2S) and carbon monoxide are also involved in physiological and pathological processes in the cardiovascular system. Nitrates that have been used for over a century and nebivolol, a third-generation b-blocker with vasodilating properties by increasing bioavailability of NO, provide convincing arguments that the compounds acting via NO pathway will remain an important class of cardiovascular drugs. A rapidly growing number of publications on functions of H2S in the circulatory system suggests that the gaseous transmitter may become a promising target for new treatment strategies in cardiovascular diseases. This review is focused on the role of gaseous transmitters in the regulation of the cardiovascular system and their pharmacotherapeutic potential.
Kardiol Pol 2010; 68, supl. V: 436-440
Get Citation

Keywords

circulatory system; nitric oxide; hydrogen sulfide; carbon monoxide; gaseous transmitters; cardiovascular diseases

About this article
Title

The role of nitric oxide, hydrogen sulfide and carbon monoxide in the regulation of the circulatory system and their pharmacotherapeutic potential

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 68, Supp. V (2010)

Pages

436-440

Published online

2010-11-25

Keywords

circulatory system
nitric oxide
hydrogen sulfide
carbon monoxide
gaseous transmitters
cardiovascular diseases

Authors

Marcin Ufnal
Tymoteusz Żera

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., Świętokrzyska 73 street, 80–180 Gdańsk, Poland

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl