open access

Vol 68, Supp. V (2010)
Review articles
Published online: 2010-11-25
Submitted: 2012-12-28
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Overview on omega-3 polyunsaturated fatty acids and heart failure

Monika K. Duda, Karen M. O’Shea, William C. Stanley

open access

Vol 68, Supp. V (2010)
Review articles
Published online: 2010-11-25
Submitted: 2012-12-28

Abstract

Despite aggressive pharmacotherapy, heart failure is still clinical problem. Current therapies improve clinical symptoms and slow progression to heart failure, but overall the prognosis remains poor. Evidence from epidemiological, clinical and experimental studies indicates a beneficial role of the omega-3 polyunsaturated fatty acids (omega-3 PUFA) found in fish oils in the prevention and management of heart failure. Although the mechanisms is still unclear, clinical and animals studies indicate that the benefits of omega-3 PUFA may be attributed to a number of distinct biological effects on lipoprotein metabolism, inflammation response and mitochondrial function. This review summarise the data related to use of omega-3 PUFA supplementation as a potential treatment for heart failure and discussed possible mechanism of action.
Kardiol Pol 2010; 68, supl. V: 400-404

Abstract

Despite aggressive pharmacotherapy, heart failure is still clinical problem. Current therapies improve clinical symptoms and slow progression to heart failure, but overall the prognosis remains poor. Evidence from epidemiological, clinical and experimental studies indicates a beneficial role of the omega-3 polyunsaturated fatty acids (omega-3 PUFA) found in fish oils in the prevention and management of heart failure. Although the mechanisms is still unclear, clinical and animals studies indicate that the benefits of omega-3 PUFA may be attributed to a number of distinct biological effects on lipoprotein metabolism, inflammation response and mitochondrial function. This review summarise the data related to use of omega-3 PUFA supplementation as a potential treatment for heart failure and discussed possible mechanism of action.
Kardiol Pol 2010; 68, supl. V: 400-404
Get Citation

Keywords

heart failure; lipoproteins; inflammation; mitochondria; omega-3 polyunsaturated fatty acids

About this article
Title

Overview on omega-3 polyunsaturated fatty acids and heart failure

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 68, Supp. V (2010)

Pages

400-404

Published online

2010-11-25

Keywords

heart failure
lipoproteins
inflammation
mitochondria
omega-3 polyunsaturated fatty acids

Authors

Monika K. Duda
Karen M. O’Shea
William C. Stanley

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