open access

Vol 69, No 12 (2011)
Original articles
Published online: 2011-12-15
Submitted: 2012-12-28
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Impact of MTHFR C677T gene polymorphism and vitamins intake on homocysteine concentration in the Polish adult population

Anna Waśkiewicz, Walerian Piotrowski, Grażyna Broda, Agnieszka Sobczyk-Kopcioł, Rafał Płoski
Kardiol Pol 2011;69(12):1259-1264.

open access

Vol 69, No 12 (2011)
Original articles
Published online: 2011-12-15
Submitted: 2012-12-28

Abstract

Background: Homocysteine (Hcy) levels are modulated by nutritional and genetic factors, among which is the enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR).
Aim: To determine the effects of the MTHTR C677T polymorphism, as well as the intake of folate, vitamins B6 and B12 on serum Hcy concentration in the Polish population.
Methods: Within the framework of the National Multicentre Health Survey (WOBASZ), a representative sample of the whole Polish population aged 20–74 was screened in 2003–2005. Vitamins intake, Hcy level and known MTHTR C677T genotype were available for 1,561 men and 1,712 women.
Results: In the Polish population, T/T, C/T and C/C genotype frequencies were 10%, 43% and 47%, respectively in men, and 9%, 42% and 49%, respectively in women. The T/T genotype was associated with increased levels of Hcy (13.14 μmol/L in men, and 9.77 mmol/L in women) compared to the C/C and C/T genotypes (10.18 and 8.77, respectively), after adjustment for age, methionine, coffee and alcohol intake, smoking and drugs used. In a multivariable linear regression model, among subjects with the T/T genotype, the only factor influencing Hcy was age in women. In the case of the other groups (C/C and C/T), there was a relationship between Hcy and age, alcohol consumption, drugs used, folate and vitamin B6 in men, and age, smoking, coffee consumption, drugs used, folate and vitamin B12 in women.
Conclusions: The T/T genotype is associated with higher levels of Hcy (29% in men, and 11% in women) compared to other genotypes. Nutritional factors affect Hcy levels only in the C/C and C/T MTHFR genotypes.
Kardiol Pol 2011; 69, 12: 1259–1264

Abstract

Background: Homocysteine (Hcy) levels are modulated by nutritional and genetic factors, among which is the enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR).
Aim: To determine the effects of the MTHTR C677T polymorphism, as well as the intake of folate, vitamins B6 and B12 on serum Hcy concentration in the Polish population.
Methods: Within the framework of the National Multicentre Health Survey (WOBASZ), a representative sample of the whole Polish population aged 20–74 was screened in 2003–2005. Vitamins intake, Hcy level and known MTHTR C677T genotype were available for 1,561 men and 1,712 women.
Results: In the Polish population, T/T, C/T and C/C genotype frequencies were 10%, 43% and 47%, respectively in men, and 9%, 42% and 49%, respectively in women. The T/T genotype was associated with increased levels of Hcy (13.14 μmol/L in men, and 9.77 mmol/L in women) compared to the C/C and C/T genotypes (10.18 and 8.77, respectively), after adjustment for age, methionine, coffee and alcohol intake, smoking and drugs used. In a multivariable linear regression model, among subjects with the T/T genotype, the only factor influencing Hcy was age in women. In the case of the other groups (C/C and C/T), there was a relationship between Hcy and age, alcohol consumption, drugs used, folate and vitamin B6 in men, and age, smoking, coffee consumption, drugs used, folate and vitamin B12 in women.
Conclusions: The T/T genotype is associated with higher levels of Hcy (29% in men, and 11% in women) compared to other genotypes. Nutritional factors affect Hcy levels only in the C/C and C/T MTHFR genotypes.
Kardiol Pol 2011; 69, 12: 1259–1264
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Keywords

MTHFR C677T; folate; vitamin B6; vitamin B12; homocysteine

About this article
Title

Impact of MTHFR C677T gene polymorphism and vitamins intake on homocysteine concentration in the Polish adult population

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 69, No 12 (2011)

Pages

1259-1264

Published online

2011-12-15

Bibliographic record

Kardiol Pol 2011;69(12):1259-1264.

Keywords

MTHFR C677T
folate
vitamin B6
vitamin B12
homocysteine

Authors

Anna Waśkiewicz
Walerian Piotrowski
Grażyna Broda
Agnieszka Sobczyk-Kopcioł
Rafał Płoski

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