open access

Vol 69, No 3 (2011)
Original articles
Published online: 2011-03-22
Submitted: 2012-12-28
Get Citation

Does contrast agent injection during trans-catheter aortic valve implantation negatively affect kidney function?

Ewa Podolecka, Zbigniew Chmielak, Marcin Demkow, Piotr Michałek, Ewa Księżycka-Majczyńska, Stefania Lidia Chojnowska, Tomasz Hryniewiecki, Krzysztof Kuśmierski, Zbigniew Juraszyński, Katarzyna Czerwińska, Ewa Sitkowska-Rysiak, Janina Stępińska, Witold Rużyłło, Adam Witkowski
Kardiol Pol 2011;69(3):251-255.

open access

Vol 69, No 3 (2011)
Original articles
Published online: 2011-03-22
Submitted: 2012-12-28

Abstract


Background: Trans-catheter aortic valve implantation (TAVI) has recently emerged as an alternative to conventional surgery in high-risk surgical patients with haemodynamically significant aortic valve stenosis. However, patients referred for TAVI are usually elderly individuals (> 80 years) who frequently also suffer from renal impairment. Trans-catheter valve therapies require extensive use of contrast injections with a risk of nephrotoxicity.
Aim: To evaluate post-TAVI renal function and to determine whether the exposure to contrast injections might cause reduced kidney function and contrast-induced nephropathy.
Methods: From January 2009 to September 2010, TAVI was performed in 39 patients (26 women and 13 men). The mean age of the patients was 81.43 ± 7.39 years, and the mean volume of contrast material administered was 187.95 ± 91.34 mL. Serum creatinine and glomerular filtration rate (GFR, acc. to the MDRD formula) were estimated in all patients prior to and 1, 2, and 5-8 days after TAVI. Results: Two female patients died on postoperative day 1. Other patients did not show clinically significant reduction in renal function following the procedure (mean creatinine concentration 104.46 vs 99.77 vs 94.56 vs 93.64 mmol/L, NS and mean GFR 52.37 vs 56.63 vs 60.18 vs 61.34 mL/min/1.73 m2, NS).
Conclusions: 1. The TAVI procedure, which includes contrast injection does not seem to cause a clinically significant decrease of renal function. 2. None of our elderly patients with severe aortic valve stenosis, multiple co-morbidities, and pre- TAVI renal compromise developed contrast-induced nephropathy.
Kardiol Pol 2011; 69, 3: 251-255

Abstract


Background: Trans-catheter aortic valve implantation (TAVI) has recently emerged as an alternative to conventional surgery in high-risk surgical patients with haemodynamically significant aortic valve stenosis. However, patients referred for TAVI are usually elderly individuals (> 80 years) who frequently also suffer from renal impairment. Trans-catheter valve therapies require extensive use of contrast injections with a risk of nephrotoxicity.
Aim: To evaluate post-TAVI renal function and to determine whether the exposure to contrast injections might cause reduced kidney function and contrast-induced nephropathy.
Methods: From January 2009 to September 2010, TAVI was performed in 39 patients (26 women and 13 men). The mean age of the patients was 81.43 ± 7.39 years, and the mean volume of contrast material administered was 187.95 ± 91.34 mL. Serum creatinine and glomerular filtration rate (GFR, acc. to the MDRD formula) were estimated in all patients prior to and 1, 2, and 5-8 days after TAVI. Results: Two female patients died on postoperative day 1. Other patients did not show clinically significant reduction in renal function following the procedure (mean creatinine concentration 104.46 vs 99.77 vs 94.56 vs 93.64 mmol/L, NS and mean GFR 52.37 vs 56.63 vs 60.18 vs 61.34 mL/min/1.73 m2, NS).
Conclusions: 1. The TAVI procedure, which includes contrast injection does not seem to cause a clinically significant decrease of renal function. 2. None of our elderly patients with severe aortic valve stenosis, multiple co-morbidities, and pre- TAVI renal compromise developed contrast-induced nephropathy.
Kardiol Pol 2011; 69, 3: 251-255
Get Citation

Keywords

aortic stenosis; contrast; nephropathy; trans-catheter aortic valve implantation

About this article
Title

Does contrast agent injection during trans-catheter aortic valve implantation negatively affect kidney function?

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 69, No 3 (2011)

Pages

251-255

Published online

2011-03-22

Bibliographic record

Kardiol Pol 2011;69(3):251-255.

Keywords

aortic stenosis
contrast
nephropathy
trans-catheter aortic valve implantation

Authors

Ewa Podolecka
Zbigniew Chmielak
Marcin Demkow
Piotr Michałek
Ewa Księżycka-Majczyńska
Stefania Lidia Chojnowska
Tomasz Hryniewiecki
Krzysztof Kuśmierski
Zbigniew Juraszyński
Katarzyna Czerwińska
Ewa Sitkowska-Rysiak
Janina Stępińska
Witold Rużyłło
Adam Witkowski

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., Świętokrzyska 73 street, 80–180 Gdańsk, Poland

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl