open access

Vol 69, No 4 (2011)
Review articles
Published online: 2011-04-26
Submitted: 2012-12-28
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Chronic inflammation in patients with acute coronary syndrome and chronic kidney disease

Aleksander Owczarek, Magdalena Babińska, Bożena Szyguła-Jurkiewicz, Jerzy Chudek
Kardiol Pol 2011;69(4):388-393.

open access

Vol 69, No 4 (2011)
Review articles
Published online: 2011-04-26
Submitted: 2012-12-28

Abstract

Chronic kidney disease is a worldwide growing problem in public health. It is a risk factor for complications in patients with acute coronary syndrome (ACS). Diabetes, hypertension (hypertrophy and left ventricular failure), impaired fibrinolysis and coagulation processes, as well as the rapid development of atherosclerosis (partly associated with chronic inflammation) are responsible for higher prevalence of cardiovascular diseases in patients with chronic kidney disease. Inflammatory process of unknown aetiology belongs to the so-called non-traditional risk factors in development of cardiovascular system diseases. It is thought that this process is responsible for adverse remodelling of atherosclerosis plaque and its instability which causes plaque rupture and as a result a coronary syndrome occurrence. Important inflammatory mediators, which take part in pathogenesis of ACS, are acute phase proteins such as: C-reactive protein, adhesion molecules VCAM-1, ICAM-1, selectins, plasma amyloid A, metalloproteinases, interleukins-1 and -6, tumour necrosis factor-a and vascular endothelial growth factor.
Kardiol Pol 2011; 69, 4: 388-393

Abstract

Chronic kidney disease is a worldwide growing problem in public health. It is a risk factor for complications in patients with acute coronary syndrome (ACS). Diabetes, hypertension (hypertrophy and left ventricular failure), impaired fibrinolysis and coagulation processes, as well as the rapid development of atherosclerosis (partly associated with chronic inflammation) are responsible for higher prevalence of cardiovascular diseases in patients with chronic kidney disease. Inflammatory process of unknown aetiology belongs to the so-called non-traditional risk factors in development of cardiovascular system diseases. It is thought that this process is responsible for adverse remodelling of atherosclerosis plaque and its instability which causes plaque rupture and as a result a coronary syndrome occurrence. Important inflammatory mediators, which take part in pathogenesis of ACS, are acute phase proteins such as: C-reactive protein, adhesion molecules VCAM-1, ICAM-1, selectins, plasma amyloid A, metalloproteinases, interleukins-1 and -6, tumour necrosis factor-a and vascular endothelial growth factor.
Kardiol Pol 2011; 69, 4: 388-393
Get Citation

Keywords

chronic inflammation; acute coronary syndrome; chronic kidney disease; risk factors

About this article
Title

Chronic inflammation in patients with acute coronary syndrome and chronic kidney disease

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 69, No 4 (2011)

Pages

388-393

Published online

2011-04-26

Bibliographic record

Kardiol Pol 2011;69(4):388-393.

Keywords

chronic inflammation
acute coronary syndrome
chronic kidney disease
risk factors

Authors

Aleksander Owczarek
Magdalena Babińska
Bożena Szyguła-Jurkiewicz
Jerzy Chudek

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