open access

Vol 69, Supp. III (2011)
Reviews
Published online: 2011-11-24
Submitted: 2012-12-28
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Endogenous cardioprotective mechanisms — what is it about and how does it work?

Andrzej Beręsewicz

open access

Vol 69, Supp. III (2011)
Reviews
Published online: 2011-11-24
Submitted: 2012-12-28

Abstract

Reperfusion therapy is the primary treatment for acute myocardial infarction. Its infarct-limiting effectiveness is, however, limited by so called reperfusion-induced myocardial injury likely related to reperfusion-mediated opening of the mitochondrial permeability transition pore (mPTP). While pharmacologic cardioprotection has proved to effectively reduce infarct size in the experimental models its clinical usefulness is problematic. In this context, a clinical exploitation of endogenous cardioprotective mechanisms, known as ischaemic preconditioning and ischaemic postconditioning, emerges as an attractive therapeutic alternative. This is particularly so because ischaemic pre- and post-conditionig seem to afford cardioprotection by preventing reperfusion-induced deleterious opening of mPTP.
Kardiol Pol 2011; 69, supl. III: 59–66

Abstract

Reperfusion therapy is the primary treatment for acute myocardial infarction. Its infarct-limiting effectiveness is, however, limited by so called reperfusion-induced myocardial injury likely related to reperfusion-mediated opening of the mitochondrial permeability transition pore (mPTP). While pharmacologic cardioprotection has proved to effectively reduce infarct size in the experimental models its clinical usefulness is problematic. In this context, a clinical exploitation of endogenous cardioprotective mechanisms, known as ischaemic preconditioning and ischaemic postconditioning, emerges as an attractive therapeutic alternative. This is particularly so because ischaemic pre- and post-conditionig seem to afford cardioprotection by preventing reperfusion-induced deleterious opening of mPTP.
Kardiol Pol 2011; 69, supl. III: 59–66
Get Citation

Keywords

myocardial reperfusion injury; cardioprotection; ischaemic preconditioning; ischaemic postconditioning; mitochondrial permeability transition pore

About this article
Title

Endogenous cardioprotective mechanisms — what is it about and how does it work?

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 69, Supp. III (2011)

Pages

59-66

Published online

2011-11-24

Keywords

myocardial reperfusion injury
cardioprotection
ischaemic preconditioning
ischaemic postconditioning
mitochondrial permeability transition pore

Authors

Andrzej Beręsewicz

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