Vol 59, No 11 (2003)
Other
Published online: 2005-12-12
Submitted: 2012-12-28
Get Citation

Cardiological syndrome X Non-invasive assessment of endothelial function and arterial compliance

Michał Kidawa, Maria Krzemińska-Pakuła, Jan Peruga, Jarosław Kasprzak, Ewa Trzos
Kardiol Pol 2003;59(11):391-396.
Vol 59, No 11 (2003)
Other
Published online: 2005-12-12
Submitted: 2012-12-28

Abstract

Background: Mechanisms responsible for cardiological syndrome X are complex and not well understood. It has been postulated that impaired endothelial function and abnormal reactivity of coronary vessels may play a role in the pathogenesis of this condition.
Aim: To assess mechanical properties of peripheral arterial vessels and both endothelium-dependent and endotheliumindependent vessel reactivity in patients with or without atherosclerotic lesions in coronary arteries.
Methods: The study group consisted of 100 patients with typical angina and positive exercise test who underwent coronary angiography. Based on angiographic results, the patients were divided into two groups: 50 patients with normal coronary angiograms and 50 age- and gender-matched patients with at least one significant coronary artery lesion (coronary artery disease (CAD) group). The control group consisted of 40 healthy volunteers without risk factors of atherosclerosis. The compliance of arterial vessels was assessed by automatic measurement of pulse wave velocity (PWV). Endothelial function was examined by ultrasonographic measurement of the diameter of brachial artery following passive hyperaemia (endothelium-dependent vessel distension) and following nitroglycerine (endothelium-independent mechanism).
Results: Among all three studied groups, the PWV values were the highest in patients with CAD. Patients with syndrome X had significantly higher PWV than in controls. A cut-off PWV value of 10.5 m/s distinguished patients with syndrome X from those with CAD. Endothelium-dependent arterial distensibility was significantly lower in patients with syndrome X than in controls; the lowest values were observed in patients with CAD. Among patients with syndrome X, the endothelium-dependent arterial vessel distensibility was the only parameter significantly influencing PWV results.
Conclusions: PWV was significantly increased in patients with syndrome X which suggests a decreased arterial vessel compliance. These results and the impairment of endothelium-dependent relaxation suggest a similar pathomechanism of altered arterial reactivity in patients with syndrome X and in patients with CAD.

Abstract

Background: Mechanisms responsible for cardiological syndrome X are complex and not well understood. It has been postulated that impaired endothelial function and abnormal reactivity of coronary vessels may play a role in the pathogenesis of this condition.
Aim: To assess mechanical properties of peripheral arterial vessels and both endothelium-dependent and endotheliumindependent vessel reactivity in patients with or without atherosclerotic lesions in coronary arteries.
Methods: The study group consisted of 100 patients with typical angina and positive exercise test who underwent coronary angiography. Based on angiographic results, the patients were divided into two groups: 50 patients with normal coronary angiograms and 50 age- and gender-matched patients with at least one significant coronary artery lesion (coronary artery disease (CAD) group). The control group consisted of 40 healthy volunteers without risk factors of atherosclerosis. The compliance of arterial vessels was assessed by automatic measurement of pulse wave velocity (PWV). Endothelial function was examined by ultrasonographic measurement of the diameter of brachial artery following passive hyperaemia (endothelium-dependent vessel distension) and following nitroglycerine (endothelium-independent mechanism).
Results: Among all three studied groups, the PWV values were the highest in patients with CAD. Patients with syndrome X had significantly higher PWV than in controls. A cut-off PWV value of 10.5 m/s distinguished patients with syndrome X from those with CAD. Endothelium-dependent arterial distensibility was significantly lower in patients with syndrome X than in controls; the lowest values were observed in patients with CAD. Among patients with syndrome X, the endothelium-dependent arterial vessel distensibility was the only parameter significantly influencing PWV results.
Conclusions: PWV was significantly increased in patients with syndrome X which suggests a decreased arterial vessel compliance. These results and the impairment of endothelium-dependent relaxation suggest a similar pathomechanism of altered arterial reactivity in patients with syndrome X and in patients with CAD.
Get Citation

Keywords

syndrome x - endothelial dysfunction - coronary artery disease - arterial compliance

About this article
Title

Cardiological syndrome X Non-invasive assessment of endothelial function and arterial compliance

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 59, No 11 (2003)

Pages

391-396

Published online

2005-12-12

Bibliographic record

Kardiol Pol 2003;59(11):391-396.

Keywords

syndrome x - endothelial dysfunction - coronary artery disease - arterial compliance

Authors

Michał Kidawa
Maria Krzemińska-Pakuła
Jan Peruga
Jarosław Kasprzak
Ewa Trzos

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., Świętokrzyska 73 street, 80–180 Gdańsk, Poland

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl