Vol 59, No 12 (2003)
Other
Published online: 2005-12-12
Submitted: 2012-12-28
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Percutaneous autologous myoblast transplantation in the treatment of post-infarction myocardial contractility impairment - report on two cases

Tomasz Siminiak, Dorota Fiszer, Olga Jerzykowska, Beata Grygielska, Piotr Kałmucki, Maciej Kurpisz
Kardiol Pol 2003;59(12):497-501.
Vol 59, No 12 (2003)
Other
Published online: 2005-12-12
Submitted: 2012-12-28

Abstract

Abstract: Numerous animal experimental studies as well as the initial human experience have shown that autologous skeletal myoblast transplantation into area of post-infarction left ventricular injury results in an increase in segmental contractile performance related to contraction of cells differentiated from transplanted myoblasts. We have previously introduced skeletal myoblast transplantation performed at the time of coronary artery bypass grafting. Currently, we report the first two cases in Poland of percutaneous autologous myoblast transplantation in the treatment of post-infarction heart failure. The procedures were performed using a catheter system enabling intra-myocardial injections from the lumen of cardiac veins under intravascular ultrasound guidance. Lack of major procedural complications and expected benefits from myocardial regeneration in patients with post-infarction heart failure justify initiation of phase one clinical trial to evaluate this method.

Abstract

Abstract: Numerous animal experimental studies as well as the initial human experience have shown that autologous skeletal myoblast transplantation into area of post-infarction left ventricular injury results in an increase in segmental contractile performance related to contraction of cells differentiated from transplanted myoblasts. We have previously introduced skeletal myoblast transplantation performed at the time of coronary artery bypass grafting. Currently, we report the first two cases in Poland of percutaneous autologous myoblast transplantation in the treatment of post-infarction heart failure. The procedures were performed using a catheter system enabling intra-myocardial injections from the lumen of cardiac veins under intravascular ultrasound guidance. Lack of major procedural complications and expected benefits from myocardial regeneration in patients with post-infarction heart failure justify initiation of phase one clinical trial to evaluate this method.
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Keywords

myoblast - heart failure - transplantation

About this article
Title

Percutaneous autologous myoblast transplantation in the treatment of post-infarction myocardial contractility impairment - report on two cases

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 59, No 12 (2003)

Pages

497-501

Published online

2005-12-12

Bibliographic record

Kardiol Pol 2003;59(12):497-501.

Keywords

myoblast - heart failure - transplantation

Authors

Tomasz Siminiak
Dorota Fiszer
Olga Jerzykowska
Beata Grygielska
Piotr Kałmucki
Maciej Kurpisz

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