Vol 61, No 10 (2004)
Other
Published online: 2005-12-12
Submitted: 2012-12-28
Get Citation

Endothelin-1 plasma concentration in children and adolescents with atherogenic risk factors

Barbara Głowińska, Mirosława Urban, Andrzej Hryniewicz, Jadwiga Peczyńska, Bożena Florys, Mortada Al-Hwish
Kardiol Pol 2004;61(10):334-338.
Vol 61, No 10 (2004)
Other
Published online: 2005-12-12
Submitted: 2012-12-28

Abstract

Background: Endothelial injury is the main stimulus for endothelin-1 (ET-1) secretion - a strong vasoconstricting agent. The role of endothelial dysfunction in the pathogenesis of hypertension and atherosclerosis which already develops in childhood, has been recently underlined.
Aim: To asses plasma ET-1 concentration in children and adolescents with such atherogenic risk factors as hypertension, obesity or diabetes.
Methods: The study group consisted of 105 children and adolescents in the mean age of 15.3±2.4 years who were divided into 5 groups: (1) hypertension, (2) obesity and hypertension, (3) obesity, (4) diabetes and (5) diabetes with hypertension. The control group was composed of 32 healthy subjects of appropriate weight, aged 14.7±2.9 years. Plasma concentration of ET-1 was measured using the enzymatic method ELISA (R&D Systems).
Results: ET-1 plasma concentration was significantly higher in the whole study group than in controls (0.71 vs 0.40 pg/mL; p<0.05) as well as in each studied subgroup compared with healthy subjects (0.63 pg/mL, p<0.05; 0.88 pg/mL p<0.05; 0.96 pg/mL, p<0.05, 0.60 pg/mL, p<0.05, and 0.63, p<0.05, respectively). There was a significant correlation between ET-1 concentration and body mass index in the whole study group (p=0.001) as well as cholesterol (p=0.018) and triglyceride (p=0.001) levels. In the group of patients with hypertension, ET-1 correlated with body mass index (p=0.023) and systolic blood pressure (p=0.02).
Conclusions: Children and adolescents with hypertension, obesity or diabetes have higher ET-1 plasma concentration than healthy subjects. ET-1 level correlates with body mass index, lipid parameters and systolic blood pressure.

Abstract

Background: Endothelial injury is the main stimulus for endothelin-1 (ET-1) secretion - a strong vasoconstricting agent. The role of endothelial dysfunction in the pathogenesis of hypertension and atherosclerosis which already develops in childhood, has been recently underlined.
Aim: To asses plasma ET-1 concentration in children and adolescents with such atherogenic risk factors as hypertension, obesity or diabetes.
Methods: The study group consisted of 105 children and adolescents in the mean age of 15.3&#177;2.4 years who were divided into 5 groups: (1) hypertension, (2) obesity and hypertension, (3) obesity, (4) diabetes and (5) diabetes with hypertension. The control group was composed of 32 healthy subjects of appropriate weight, aged 14.7&#177;2.9 years. Plasma concentration of ET-1 was measured using the enzymatic method ELISA (R&D Systems).
Results: ET-1 plasma concentration was significantly higher in the whole study group than in controls (0.71 vs 0.40 pg/mL; p<0.05) as well as in each studied subgroup compared with healthy subjects (0.63 pg/mL, p<0.05; 0.88 pg/mL p<0.05; 0.96 pg/mL, p<0.05, 0.60 pg/mL, p<0.05, and 0.63, p<0.05, respectively). There was a significant correlation between ET-1 concentration and body mass index in the whole study group (p=0.001) as well as cholesterol (p=0.018) and triglyceride (p=0.001) levels. In the group of patients with hypertension, ET-1 correlated with body mass index (p=0.023) and systolic blood pressure (p=0.02).
Conclusions: Children and adolescents with hypertension, obesity or diabetes have higher ET-1 plasma concentration than healthy subjects. ET-1 level correlates with body mass index, lipid parameters and systolic blood pressure.
Get Citation

Keywords

endothelin-1 - atherogenic risk factors - endothelial dysfunction - children - adolescents

About this article
Title

Endothelin-1 plasma concentration in children and adolescents with atherogenic risk factors

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 61, No 10 (2004)

Pages

334-338

Published online

2005-12-12

Bibliographic record

Kardiol Pol 2004;61(10):334-338.

Keywords

endothelin-1 - atherogenic risk factors - endothelial dysfunction - children - adolescents

Authors

Barbara Głowińska
Mirosława Urban
Andrzej Hryniewicz
Jadwiga Peczyńska
Bożena Florys
Mortada Al-Hwish

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., Świętokrzyska 73 street, 80–180 Gdańsk, Poland

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl