Vol 61, No 11 (2004)
Other
Published online: 2005-12-12
Submitted: 2012-12-28
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The effects of genetic factors on selected indicators of the activity of the sympathoadrenal system and the renin-angiotensin-aldosterone system in twins

Piotr Jędrusik, Andrzej Januszewicz, Andreas Busjahn, Bożenna Wocial, Hanna Ignatowska-Świtalska, Jan Strelau, Friedrich C. Luft, Włodzimierz Januszewicz
Kardiol Pol 2004;61(11):427-429.
Vol 61, No 11 (2004)
Other
Published online: 2005-12-12
Submitted: 2012-12-28

Abstract

Background: There are numerous data indicating a significant role of the sympathoadrenal system and the reninangiotensin- aldosterone system in the regulation of blood pressure and the pathogenesis of essential hypertension. However, the genetic background of essential hypertension remains unclear.
Aim: To determine the effects of genetic factors on selected indicators of the activity of the sympathoadrenal system and the renin-angiotensin-aldosterone system in twins.
Methods: We studied 39 monozygotic twin pairs (age 33±7 years) and 37 same-gender dizygotic twin pairs (age 36±7 years). We measured blood and urine adrenaline (A), noradrenaline (NA), dopamine (DA) and aldosterone (ALD) levels, as well as plasma renin activity (PRA) and serum angiotensin-converting enzyme (ACE) activity. Parameters of the genetic models for age- and gender-adjusted data were estimated by model fitting and path analysis technique using LISREL 8.
Results: The effects of genetic factors on the variability of blood and urine catecholamine levels were 69% and 65% for A, 42% and 76% for NA, and 58% and 40% for DA, respectively. We also found shared environmental components for blood NA (28%) and urine DA (17%). Genetic factors accounted for 36% of the variability of PRA and 80% of the variability of ACE. ALD levels were related only to environmental factors (including a shared environmental component, estimated at 25%, for urine ALD).
Conclusions: We found significant effects of genetic factors on the activity of the sympathoadrenal system, as indicated by blood and urine catecholamine levels. We also found the effect of genetic factors on PRA and ACE, but not on aldosterone levels.

Abstract

Background: There are numerous data indicating a significant role of the sympathoadrenal system and the reninangiotensin- aldosterone system in the regulation of blood pressure and the pathogenesis of essential hypertension. However, the genetic background of essential hypertension remains unclear.
Aim: To determine the effects of genetic factors on selected indicators of the activity of the sympathoadrenal system and the renin-angiotensin-aldosterone system in twins.
Methods: We studied 39 monozygotic twin pairs (age 33±7 years) and 37 same-gender dizygotic twin pairs (age 36±7 years). We measured blood and urine adrenaline (A), noradrenaline (NA), dopamine (DA) and aldosterone (ALD) levels, as well as plasma renin activity (PRA) and serum angiotensin-converting enzyme (ACE) activity. Parameters of the genetic models for age- and gender-adjusted data were estimated by model fitting and path analysis technique using LISREL 8.
Results: The effects of genetic factors on the variability of blood and urine catecholamine levels were 69% and 65% for A, 42% and 76% for NA, and 58% and 40% for DA, respectively. We also found shared environmental components for blood NA (28%) and urine DA (17%). Genetic factors accounted for 36% of the variability of PRA and 80% of the variability of ACE. ALD levels were related only to environmental factors (including a shared environmental component, estimated at 25%, for urine ALD).
Conclusions: We found significant effects of genetic factors on the activity of the sympathoadrenal system, as indicated by blood and urine catecholamine levels. We also found the effect of genetic factors on PRA and ACE, but not on aldosterone levels.
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Keywords

adrenaline - noradrenaline - dopamine - aldosterone - renin - angiotensin-converting enzyme (ace) - genetic factors - twin studies

About this article
Title

The effects of genetic factors on selected indicators of the activity of the sympathoadrenal system and the renin-angiotensin-aldosterone system in twins

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 61, No 11 (2004)

Pages

427-429

Published online

2005-12-12

Bibliographic record

Kardiol Pol 2004;61(11):427-429.

Keywords

adrenaline - noradrenaline - dopamine - aldosterone - renin - angiotensin-converting enzyme (ace) - genetic factors - twin studies

Authors

Piotr Jędrusik
Andrzej Januszewicz
Andreas Busjahn
Bożenna Wocial
Hanna Ignatowska-Świtalska
Jan Strelau
Friedrich C. Luft
Włodzimierz Januszewicz

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