Vol 60, No 2 (2004)
Other
Published online: 2005-12-12
Submitted: 2012-12-28
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Effects of cardiopulmonary bypass on the expression of adhesive molecules in children undergoing cardiac surgery due to congenital heart disorders

Jarosław Paśnik, Zbigniew Baj, Jadwiga Moll, Jacek Moll, Maciej Moll, Lech Pokoca, Andrzej Sysa, Krzysztof Zeman
Kardiol Pol 2004;60(2):128-131.
Vol 60, No 2 (2004)
Other
Published online: 2005-12-12
Submitted: 2012-12-28

Abstract

Background: Infants and small children who undergo cardiac surgery due to congenital heart disorders, are at risk of developing inflammatory complications and multi-organ failure.
Aim: To assess the changes in the expression of adhesive molecules on neutrophils and in peripheral blood plasma in children undergoing cardiac surgery with or without the use of cardiopulmonary bypass (CPB).
Methods: In 18 children who underwent surgery with the use of CPB and in 7 children who underwent surgery without CPB, the expression of CD11b, CD11c and CD62L molecules on neutrophils and soluble adhesive molecules - L-selectin and ICAM-1, was assessed before, during and after cardiac surgery.
Results: A significant increase in the expression of CD11b on neutrophils at the time of the initiation of CPB was observed. The most pronounced decrease in the expression of CD11c was detected at the end of surgical procedure. There was also a negative correlation between L-selectin concentration measured at the end of CPB and CPB duration as well as between ICAM-1 concentration and duration of hypothermia.
Conclusions: Cardiac surgery influences the expression of adhesive molecules on neutrophils and in blood plasma. These changes are more pronounced in children who undergo CPB, and depend on CPB duration as well as the use of hypothermia.

Abstract

Background: Infants and small children who undergo cardiac surgery due to congenital heart disorders, are at risk of developing inflammatory complications and multi-organ failure.
Aim: To assess the changes in the expression of adhesive molecules on neutrophils and in peripheral blood plasma in children undergoing cardiac surgery with or without the use of cardiopulmonary bypass (CPB).
Methods: In 18 children who underwent surgery with the use of CPB and in 7 children who underwent surgery without CPB, the expression of CD11b, CD11c and CD62L molecules on neutrophils and soluble adhesive molecules - L-selectin and ICAM-1, was assessed before, during and after cardiac surgery.
Results: A significant increase in the expression of CD11b on neutrophils at the time of the initiation of CPB was observed. The most pronounced decrease in the expression of CD11c was detected at the end of surgical procedure. There was also a negative correlation between L-selectin concentration measured at the end of CPB and CPB duration as well as between ICAM-1 concentration and duration of hypothermia.
Conclusions: Cardiac surgery influences the expression of adhesive molecules on neutrophils and in blood plasma. These changes are more pronounced in children who undergo CPB, and depend on CPB duration as well as the use of hypothermia.
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Keywords

adhesive molecules - cardiopulmonary bypass - cardiac surgery

About this article
Title

Effects of cardiopulmonary bypass on the expression of adhesive molecules in children undergoing cardiac surgery due to congenital heart disorders

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 60, No 2 (2004)

Pages

128-131

Published online

2005-12-12

Bibliographic record

Kardiol Pol 2004;60(2):128-131.

Keywords

adhesive molecules - cardiopulmonary bypass - cardiac surgery

Authors

Jarosław Paśnik
Zbigniew Baj
Jadwiga Moll
Jacek Moll
Maciej Moll
Lech Pokoca
Andrzej Sysa
Krzysztof Zeman

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