Vol 60, No 4 (2004)
Other
Published online: 2005-12-12
Submitted: 2012-12-28
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L-arginine supplementation prolongs duration of exercise in congestive heart failure

Bronisław Bednarz, Tomasz Jaxa-Chamiec, Jadwiga Gębalska, Krystyna Herbaczyńska-Cedro, Leszek Ceremużyński
Kardiol Pol 2004;60(4):351-353.
Vol 60, No 4 (2004)
Other
Published online: 2005-12-12
Submitted: 2012-12-28

Abstract

Background: In congestive heart failure (CHF), endothelial dysfunction may contribute to impairment of exerciseinduced vasodilatation and decreased exercise capacity. We hypothesised that administration of L-arginine, a precursor of nitric oxide (NO) and postulated antioxidant, may improve endothelium - dependent vasodilatation and exercise capacity and also exert antioxidant activity.
Aims: To investigate the effect of oral supplementation with L-arginine on exercise capacity and markers of oxidative stress in patients with mild to moderate CHF.
Methods: The study had a randomised double-blind cross-over design. Twenty one patients with stable NYHA II-III CHF underwent three exercise tests: initially, after oral administration of L-arginine (9 g/day for 7 days) or placebo. Blood was sampled prior to each test for plasma lipid peroxides, reduced sulphydryl groups and leukocyte oxygen free radical production.
Results: We found a higher prolongation of exercise duration time after L-arginine than after placebo (99±106 vs 70±99 s, p

Abstract

Background: In congestive heart failure (CHF), endothelial dysfunction may contribute to impairment of exerciseinduced vasodilatation and decreased exercise capacity. We hypothesised that administration of L-arginine, a precursor of nitric oxide (NO) and postulated antioxidant, may improve endothelium - dependent vasodilatation and exercise capacity and also exert antioxidant activity.
Aims: To investigate the effect of oral supplementation with L-arginine on exercise capacity and markers of oxidative stress in patients with mild to moderate CHF.
Methods: The study had a randomised double-blind cross-over design. Twenty one patients with stable NYHA II-III CHF underwent three exercise tests: initially, after oral administration of L-arginine (9 g/day for 7 days) or placebo. Blood was sampled prior to each test for plasma lipid peroxides, reduced sulphydryl groups and leukocyte oxygen free radical production.
Results: We found a higher prolongation of exercise duration time after L-arginine than after placebo (99±106 vs 70±99 s, p
Get Citation

Keywords

l-arginine - nitric oxide congestive heart failure - antioxidants - exercise

About this article
Title

L-arginine supplementation prolongs duration of exercise in congestive heart failure

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 60, No 4 (2004)

Pages

351-353

Published online

2005-12-12

Bibliographic record

Kardiol Pol 2004;60(4):351-353.

Keywords

l-arginine - nitric oxide congestive heart failure - antioxidants - exercise

Authors

Bronisław Bednarz
Tomasz Jaxa-Chamiec
Jadwiga Gębalska
Krystyna Herbaczyńska-Cedro
Leszek Ceremużyński

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