Vol 60, No 5 (2004)
Other
Published online: 2005-12-12
Submitted: 2012-12-28
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Atorvastatin treatment decreases inflammatory and proteolytic activity in patients with hypercholesterolemia

Ertugrul Ercan, Istemihan Tengiz, Imre Altuglu, Cevat Sekuri, Emil Aliyev, H. Ercan, Mustafa Akin
Kardiol Pol 2004;60(5):458-458.
Vol 60, No 5 (2004)
Other
Published online: 2005-12-12
Submitted: 2012-12-28

Abstract

Background: Statins have anti-inflammatory and anti-platelet effects, which are known as non-lipid effects. Statin treatment can decrease endogenous inflammatory response.
Aim: To study the effects of atorvastatin on matrix metalloproteinase-9 (MMP-9) and high sensitive C-reactive protein (hs-CRP) - markers of the proteinolytic and inflammatory activity.
Methods: In this prospective study 44 patients with hypercholesterolemia were randomly assigned into 2 groups; Group 1 (n=22) treated with atorvastatin and diet for 2 months, and Group 2 (n=22) - diet alone. MMP-9 and hs-CRP were measured at baseline and two months later.
Results: Groups were matched for age, sex and baseline characteristics. Lipid levels decreased by 32% (LDL from 153.9±26.6 to 94.5±20.8 mg/dl, p

Abstract

Background: Statins have anti-inflammatory and anti-platelet effects, which are known as non-lipid effects. Statin treatment can decrease endogenous inflammatory response.
Aim: To study the effects of atorvastatin on matrix metalloproteinase-9 (MMP-9) and high sensitive C-reactive protein (hs-CRP) - markers of the proteinolytic and inflammatory activity.
Methods: In this prospective study 44 patients with hypercholesterolemia were randomly assigned into 2 groups; Group 1 (n=22) treated with atorvastatin and diet for 2 months, and Group 2 (n=22) - diet alone. MMP-9 and hs-CRP were measured at baseline and two months later.
Results: Groups were matched for age, sex and baseline characteristics. Lipid levels decreased by 32% (LDL from 153.9±26.6 to 94.5±20.8 mg/dl, p
Get Citation

Keywords

statins - mmp-9 - c-reactive protein - hypercholesterolemia - inflammation

About this article
Title

Atorvastatin treatment decreases inflammatory and proteolytic activity in patients with hypercholesterolemia

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 60, No 5 (2004)

Pages

458-458

Published online

2005-12-12

Bibliographic record

Kardiol Pol 2004;60(5):458-458.

Keywords

statins - mmp-9 - c-reactive protein - hypercholesterolemia - inflammation

Authors

Ertugrul Ercan
Istemihan Tengiz
Imre Altuglu
Cevat Sekuri
Emil Aliyev
H. Ercan
Mustafa Akin

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