Vol 61, No 7 (2004)
Other
Published online: 2005-12-12
Submitted: 2012-12-28
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Heart rate variability in workers chronically exposed to lead

Jacek Gajek, Dorota Zyśko, Ewa Chlebda
Kardiol Pol 2004;61(7):26-30.
Vol 61, No 7 (2004)
Other
Published online: 2005-12-12
Submitted: 2012-12-28

Abstract

Background: Lead is a strong neurotoxine. The effects of lead on the activity of the autonomic nervous system, assessed by the use of heart rate variability (HRV) analysis, have not yet been established.
Aim: To assess the effects of occupational chronic lead exposure on the autonomic nervous system activity.
Methods: The study group consisted of 22 copper foundry workers (mean age 41.8±8.7 years) who had elevated parameters of lead overload and were admitted to the hospital for chelate therapy. The control group consisted of 13 age-matched healthy males. Lead concentration was measured with the use of atomic absorption spectophotometry, and concentration of free protoporphyrines in erythrocytes (FEP) using a fluorometric method. Each patient underwent 24-hour ambulatory ECG monitoring, and standard short-term as well as long-term HRV parameters were obtained.
Results: There were no significant differences between patients and controls in HRV parameters. In the control group, HRV parameters correlated with age. In patients, a significant negative correlation between lead concentration and some short-term HRV parameters calculated during the night was found: SDNN (r=-0.48, p

Abstract

Background: Lead is a strong neurotoxine. The effects of lead on the activity of the autonomic nervous system, assessed by the use of heart rate variability (HRV) analysis, have not yet been established.
Aim: To assess the effects of occupational chronic lead exposure on the autonomic nervous system activity.
Methods: The study group consisted of 22 copper foundry workers (mean age 41.8±8.7 years) who had elevated parameters of lead overload and were admitted to the hospital for chelate therapy. The control group consisted of 13 age-matched healthy males. Lead concentration was measured with the use of atomic absorption spectophotometry, and concentration of free protoporphyrines in erythrocytes (FEP) using a fluorometric method. Each patient underwent 24-hour ambulatory ECG monitoring, and standard short-term as well as long-term HRV parameters were obtained.
Results: There were no significant differences between patients and controls in HRV parameters. In the control group, HRV parameters correlated with age. In patients, a significant negative correlation between lead concentration and some short-term HRV parameters calculated during the night was found: SDNN (r=-0.48, p
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Keywords

lead - occupational exposure - heart rate variability - autonomic system

About this article
Title

Heart rate variability in workers chronically exposed to lead

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 61, No 7 (2004)

Pages

26-30

Published online

2005-12-12

Bibliographic record

Kardiol Pol 2004;61(7):26-30.

Keywords

lead - occupational exposure - heart rate variability - autonomic system

Authors

Jacek Gajek
Dorota Zyśko
Ewa Chlebda

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