Vol 61, No 7 (2004)
Other
Published online: 2005-12-12
Submitted: 2012-12-28
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Genetic factors in hypertension. Angiotensin-converting enzyme polymorphism

Danuta Czarnecka, Kalina Kawecka-Jaszcz, Katarzyna Stolarz, Agnieszka Olszanecka, Beata Kieć-Wilk, Aldona Dembińska-Kieć
Kardiol Pol 2004;61(7):6-10.
Vol 61, No 7 (2004)
Other
Published online: 2005-12-12
Submitted: 2012-12-28

Abstract

Aim: The key enzyme of the renin-angiotensin-aldosterone system angiotensin-converting enzyme (ACE), shows the genetic polymorphism responsible for the varying activity of this enzyme. In a study of randomly chosen families we analyzed the relationship between insertion/deletion (I/D) polymorphism of the ACE and ambulatory blood pressure (ABP), left ventricular mass index (LVMI) and carotid intima-media thickness (IMT).
Methods: The study population consisted of 127 parents and 167 offspring. All subjects underwent 24hr ABP monitoring using a SpaceLabs 90207 device. 2D and M-mode echocardiograms were also obtained. The carotid intima-media thickness (IMT) was assessed by ultrasound. The I/D polymorphism of the ACE gene was measured with the use of PCR method. For statistical analysis, co-variables and correlations between relatives were taken into account.
Results: The frequency of genotypes was: 27.2% for DD homozygotes, 49.7% for DI heterozygotes and 23.1% for II homozygotes, being in Hardy-Weinberg equilibrium (P=0.97). There was no relationship between the ACE gene polymorphism and ABP, LVMI or carotid IMT in parents nor their offspring. The transmission disequilibrium tests for quantitative traits showed only a slight tendency towards the influence of the polymorphism on LVMI (P=0.06).
Conclusions: In the study group of nuclear families, I/D polymorphism of the ACE gene did not influence blood pressure, left ventricular mass or carotid intima-media thickness.

Abstract

Aim: The key enzyme of the renin-angiotensin-aldosterone system angiotensin-converting enzyme (ACE), shows the genetic polymorphism responsible for the varying activity of this enzyme. In a study of randomly chosen families we analyzed the relationship between insertion/deletion (I/D) polymorphism of the ACE and ambulatory blood pressure (ABP), left ventricular mass index (LVMI) and carotid intima-media thickness (IMT).
Methods: The study population consisted of 127 parents and 167 offspring. All subjects underwent 24hr ABP monitoring using a SpaceLabs 90207 device. 2D and M-mode echocardiograms were also obtained. The carotid intima-media thickness (IMT) was assessed by ultrasound. The I/D polymorphism of the ACE gene was measured with the use of PCR method. For statistical analysis, co-variables and correlations between relatives were taken into account.
Results: The frequency of genotypes was: 27.2% for DD homozygotes, 49.7% for DI heterozygotes and 23.1% for II homozygotes, being in Hardy-Weinberg equilibrium (P=0.97). There was no relationship between the ACE gene polymorphism and ABP, LVMI or carotid IMT in parents nor their offspring. The transmission disequilibrium tests for quantitative traits showed only a slight tendency towards the influence of the polymorphism on LVMI (P=0.06).
Conclusions: In the study group of nuclear families, I/D polymorphism of the ACE gene did not influence blood pressure, left ventricular mass or carotid intima-media thickness.
Get Citation

Keywords

24-hour ambulatory blood pressure monitoring - blood pressure - carotid intima-media thickness - angiotensin-converting enzyme polymorphism

About this article
Title

Genetic factors in hypertension. Angiotensin-converting enzyme polymorphism

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 61, No 7 (2004)

Pages

6-10

Published online

2005-12-12

Bibliographic record

Kardiol Pol 2004;61(7):6-10.

Keywords

24-hour ambulatory blood pressure monitoring - blood pressure - carotid intima-media thickness - angiotensin-converting enzyme polymorphism

Authors

Danuta Czarnecka
Kalina Kawecka-Jaszcz
Katarzyna Stolarz
Agnieszka Olszanecka
Beata Kieć-Wilk
Aldona Dembińska-Kieć

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