Vol 61, No 8 (2004)
Other
Published online: 2005-12-12
Submitted: 2012-12-28
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Interaction between inflammation and thrombosis in acute coronary syndrome

Olena Lytvyn, Mykola Kopitsa, Olga Petyunina
Kardiol Pol 2004;61(8):113-113.
Vol 61, No 8 (2004)
Other
Published online: 2005-12-12
Submitted: 2012-12-28

Abstract

Background: Inflammation and thrombosis are important in the pathogenesis of acute coronary syndrome (ACS). Cytokines [interleukin-1β (IL-1β) and interleukin-6 (IL-6)] are inflammation markers which play a major role in the development of coronary heart disease. Experimental data documented that an increase of cytokine and von Willebrand factor (vWF) levels in unstable angina (UA) and non-Q wave myocardial infarction (MI) predicts an adverse outcome.
Aim: To examine the correlation between the IL-1β, IL-6 and vWF levels in patients with ACS.
Methods: We examined 92 patients (74 men, 18 women, aged from 43 to 76) divided into 3 groups. The first group included 43 patients with a Q-wave MI, the second group - 33 with a non-Q-wave MI, and the third group - 18 with UA. All patients were given 125-250 mg of aspirin and bolus of 5.000 units of unfractionated heparin, followed by heparin infusion titrated to maintain an activated partial thromboplastin time of 50-75 s. Patients with a Q-wave MI received thrombolytic therapy 1.5 million units of streptokinase. The IL-1b, IL-6 and vWF levels was measured on admission and 7 as well as 21 days later. Fifteen patients with stable angina served as the control group.
Results: The levels of cytokines and vWF were significantly higher in patients with ACS than in control subjects. A significant correlation between vWF and IL-6 levels, measured on admission and 7 days later, was found in patients with UA (r=+0.74 and r=+0.55, respectively). Also, a significant correlation was found between vWF and IL-1β levels measured on admission in patients with either Q-wave or non-Q wave MI (r=+0.7 and r=+0.61, respectively).
Conclusions: Our data suggest that there is a positive correlation between inflammation and thrombosis markers in patients with ACS.

Abstract

Background: Inflammation and thrombosis are important in the pathogenesis of acute coronary syndrome (ACS). Cytokines [interleukin-1β (IL-1β) and interleukin-6 (IL-6)] are inflammation markers which play a major role in the development of coronary heart disease. Experimental data documented that an increase of cytokine and von Willebrand factor (vWF) levels in unstable angina (UA) and non-Q wave myocardial infarction (MI) predicts an adverse outcome.
Aim: To examine the correlation between the IL-1β, IL-6 and vWF levels in patients with ACS.
Methods: We examined 92 patients (74 men, 18 women, aged from 43 to 76) divided into 3 groups. The first group included 43 patients with a Q-wave MI, the second group - 33 with a non-Q-wave MI, and the third group - 18 with UA. All patients were given 125-250 mg of aspirin and bolus of 5.000 units of unfractionated heparin, followed by heparin infusion titrated to maintain an activated partial thromboplastin time of 50-75 s. Patients with a Q-wave MI received thrombolytic therapy 1.5 million units of streptokinase. The IL-1b, IL-6 and vWF levels was measured on admission and 7 as well as 21 days later. Fifteen patients with stable angina served as the control group.
Results: The levels of cytokines and vWF were significantly higher in patients with ACS than in control subjects. A significant correlation between vWF and IL-6 levels, measured on admission and 7 days later, was found in patients with UA (r=+0.74 and r=+0.55, respectively). Also, a significant correlation was found between vWF and IL-1β levels measured on admission in patients with either Q-wave or non-Q wave MI (r=+0.7 and r=+0.61, respectively).
Conclusions: Our data suggest that there is a positive correlation between inflammation and thrombosis markers in patients with ACS.
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Keywords

acute coronary syndrome - cytokines (interleukin-1 and interleukin-6) -von willebrand factor

About this article
Title

Interaction between inflammation and thrombosis in acute coronary syndrome

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 61, No 8 (2004)

Pages

113-113

Published online

2005-12-12

Bibliographic record

Kardiol Pol 2004;61(8):113-113.

Keywords

acute coronary syndrome - cytokines (interleukin-1 and interleukin-6) -von willebrand factor

Authors

Olena Lytvyn
Mykola Kopitsa
Olga Petyunina

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