open access

Vol 70, No 10 (2012)
Original articles
Published online: 2012-10-19
Submitted: 2012-12-28
Get Citation

IgG, IgM and inflammatory markers serum concentration in patients with acute coronary syndrome: a pilot study

Łukasz Kołtowski, Krzysztof J. Filipiak, Adam Rdzanek, Violetta Stępień, Bożenna Tarchalska−Kryńska, Grzegorz Opolski
Kardiol Pol 2012;70(10):1023-1028.

open access

Vol 70, No 10 (2012)
Original articles
Published online: 2012-10-19
Submitted: 2012-12-28

Abstract

Background: A number of biomarkers have been found that might help to predict the risk of acute coronary syndrome (ACS) in adults.
Aim: To analyse the association between immunoglobulins concentration and other inflammatory markers such as C-reactive protein (CRP) and fibrinogen that show correlation with the risk of ACS.
Methods: The study population consists of 52 consecutive patients with ST segment elevation myocardial infarction (STEMI) or unstable angina/non-STEMI. Concentrations of total protein, albumin, alpha-1 globulin, beta globulin, gamma protein, immunoglobulin in class A (IgA), G (IgG), M (IgM) and E (IgE), creatinine kinase (CK), creatinine kinase MB (CK-MB), CRP and fibrinogen were quantified.
Results: In the ACS patients, there was a significant increase in gamma globulin, CRP and fibrinogen. IgG was elevated only in the STEMI group and correlated with fibrinogen (R = 0.48, p < 0.01).
Conclusions: 1. IgG appears to be the only immunoglobulin associated with ACS in the STEMI group. 2. Fibrinogen reveals features of a reactive biomarker of ACS. 3. CRP appears to be closely related to the causative process in coronary artery disease patients.

Abstract

Background: A number of biomarkers have been found that might help to predict the risk of acute coronary syndrome (ACS) in adults.
Aim: To analyse the association between immunoglobulins concentration and other inflammatory markers such as C-reactive protein (CRP) and fibrinogen that show correlation with the risk of ACS.
Methods: The study population consists of 52 consecutive patients with ST segment elevation myocardial infarction (STEMI) or unstable angina/non-STEMI. Concentrations of total protein, albumin, alpha-1 globulin, beta globulin, gamma protein, immunoglobulin in class A (IgA), G (IgG), M (IgM) and E (IgE), creatinine kinase (CK), creatinine kinase MB (CK-MB), CRP and fibrinogen were quantified.
Results: In the ACS patients, there was a significant increase in gamma globulin, CRP and fibrinogen. IgG was elevated only in the STEMI group and correlated with fibrinogen (R = 0.48, p < 0.01).
Conclusions: 1. IgG appears to be the only immunoglobulin associated with ACS in the STEMI group. 2. Fibrinogen reveals features of a reactive biomarker of ACS. 3. CRP appears to be closely related to the causative process in coronary artery disease patients.
Get Citation

Keywords

acute coronary syndrome; markers; immunoglobulin; IgG

About this article
Title

IgG, IgM and inflammatory markers serum concentration in patients with acute coronary syndrome: a pilot study

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 70, No 10 (2012)

Pages

1023-1028

Published online

2012-10-19

Bibliographic record

Kardiol Pol 2012;70(10):1023-1028.

Keywords

acute coronary syndrome
markers
immunoglobulin
IgG

Authors

Łukasz Kołtowski
Krzysztof J. Filipiak
Adam Rdzanek
Violetta Stępień
Bożenna Tarchalska−Kryńska
Grzegorz Opolski

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., Świętokrzyska 73 street, 80–180 Gdańsk, Poland

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl