Vol 62, No 1 (2005)
Other
Published online: 2005-12-12
Submitted: 2012-12-28
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Aspirin resistance in ischaemic heart disease

Wiktor Kuliczkowski, Bogumił Halawa, Bożena Korolko, Walentyna Mazurek
Kardiol Pol 2005;62(1):20-25.
Vol 62, No 1 (2005)
Other
Published online: 2005-12-12
Submitted: 2012-12-28

Abstract

Background: In spite of the usage of acetylsalicylic acid (aspirin) in the secondary prevention of ischaemic heart disease (IHD), new thrombo-embolic events occur in more than half of patients. Aspirin resistance may be partially responsible for this phenomenon.
Aim: To assess the prevalence of aspirin resistance in patients with IHD and to correlate this phenomenon with the progression of atherosclerosis, concomitant diseases and other medication.
Methods: 70%.
Results: Aspirin resistance was found in 41 (20%) patients and was significantly associated with previous coronary artery bypass grafting (CABG) (p<0.01) and three-vessel disease (p<0.05). Previous CABG was the only independent risk factor for the presence of aspirin resistance (OR 5.6; 95% CI 2.0-15.4; p<0.01).
Conclusions: Aspirin resistance is present in 20% of patients with stable angina. Previous CABG is an independent risk factor of this phenomenon.

Abstract

Background: In spite of the usage of acetylsalicylic acid (aspirin) in the secondary prevention of ischaemic heart disease (IHD), new thrombo-embolic events occur in more than half of patients. Aspirin resistance may be partially responsible for this phenomenon.
Aim: To assess the prevalence of aspirin resistance in patients with IHD and to correlate this phenomenon with the progression of atherosclerosis, concomitant diseases and other medication.
Methods: 70%.
Results: Aspirin resistance was found in 41 (20%) patients and was significantly associated with previous coronary artery bypass grafting (CABG) (p<0.01) and three-vessel disease (p<0.05). Previous CABG was the only independent risk factor for the presence of aspirin resistance (OR 5.6; 95% CI 2.0-15.4; p<0.01).
Conclusions: Aspirin resistance is present in 20% of patients with stable angina. Previous CABG is an independent risk factor of this phenomenon.
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Keywords

aspirin resistance - ischaemic heart disease - cabg

About this article
Title

Aspirin resistance in ischaemic heart disease

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 62, No 1 (2005)

Pages

20-25

Published online

2005-12-12

Bibliographic record

Kardiol Pol 2005;62(1):20-25.

Keywords

aspirin resistance - ischaemic heart disease - cabg

Authors

Wiktor Kuliczkowski
Bogumił Halawa
Bożena Korolko
Walentyna Mazurek

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