open access

Vol 63, No 12 (2005)
Other
Published online: 2005-12-14
Submitted: 2012-12-28
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ORIGINAL ARTICLE
Amiodarone after unsuccessful direct-current cardioversion of persistent atrial fibrillation

Dariusz A. Kosior, Beata Wożakowska-Kapłon, Mariusz Jasik, Marek Kiliszek, Daniel Rabczenko, Grzegorz Opolski
Kardiol Pol 2005;63(12):585-592.

open access

Vol 63, No 12 (2005)
Other
Published online: 2005-12-14
Submitted: 2012-12-28

Abstract

Aim: To assess the safety and efficacy of amiodarone used after unsuccessful direct current (DC) cardioversion of persistent atrial fibrillation (AF). Methods: The study group comprised 67 patients (F/M 26/41; mean age 61.3±11.2 years) after unsuccessful DC cardioversion (DCC) of persistent AF (mean arrhythmia duration 212.6±135.2 days) in whom another attempt of DCC was intended. Repeat DC cardioversion was performed after loading with oral amiodarone, for a period necessary to achieve a cumulative dose of up to 12.0-16.0g. Pretreatment was an outpatient procedure. After successful DC cardioversion all study subjects received a maintenance dose of amiodarone, 100-200 mg daily, aimed at preventing AF. The follow-up period was 12 months. Results: Spontaneous conversion to sinus rhythm (SR) during amiodarone pretreatment was observed in 13 pts (19.2%). DCC was performed in 54 pts and SR was restored in 41 of the study pts (76%). Complications occurred in 3 pts, including 1 case of apparent hyperthyroidism and 2 cases of decreased TSH level, and required amiodarone withdrawal. After 12 months, 72.2% of pts maintained SR on low dose (179.2±42.1 mg/day) amiodarone. Spontaneous conversion to SR during amiodarone loading was significantly related to long-term SR maintenance after successful DC cardioversion (p

Abstract

Aim: To assess the safety and efficacy of amiodarone used after unsuccessful direct current (DC) cardioversion of persistent atrial fibrillation (AF). Methods: The study group comprised 67 patients (F/M 26/41; mean age 61.3±11.2 years) after unsuccessful DC cardioversion (DCC) of persistent AF (mean arrhythmia duration 212.6±135.2 days) in whom another attempt of DCC was intended. Repeat DC cardioversion was performed after loading with oral amiodarone, for a period necessary to achieve a cumulative dose of up to 12.0-16.0g. Pretreatment was an outpatient procedure. After successful DC cardioversion all study subjects received a maintenance dose of amiodarone, 100-200 mg daily, aimed at preventing AF. The follow-up period was 12 months. Results: Spontaneous conversion to sinus rhythm (SR) during amiodarone pretreatment was observed in 13 pts (19.2%). DCC was performed in 54 pts and SR was restored in 41 of the study pts (76%). Complications occurred in 3 pts, including 1 case of apparent hyperthyroidism and 2 cases of decreased TSH level, and required amiodarone withdrawal. After 12 months, 72.2% of pts maintained SR on low dose (179.2±42.1 mg/day) amiodarone. Spontaneous conversion to SR during amiodarone loading was significantly related to long-term SR maintenance after successful DC cardioversion (p
Get Citation

Keywords

persistent atrial fibrillation; electrical cardioversion; amiodarone

About this article
Title

ORIGINAL ARTICLE
Amiodarone after unsuccessful direct-current cardioversion of persistent atrial fibrillation

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 63, No 12 (2005)

Pages

585-592

Published online

2005-12-14

Bibliographic record

Kardiol Pol 2005;63(12):585-592.

Keywords

persistent atrial fibrillation
electrical cardioversion
amiodarone

Authors

Dariusz A. Kosior
Beata Wożakowska-Kapłon
Mariusz Jasik
Marek Kiliszek
Daniel Rabczenko
Grzegorz Opolski

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