open access

Vol 70, No 11 (2012)
Invasive cardiology
Published online: 2012-11-21
Submitted: 2012-12-28
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The role of haemodynamic factors in the development of in-stent restenosis

Jarosław Wasilewski, Tadeusz Osadnik, Sylwia Peryt−Stawiarska, Lech Poloński
Kardiol Pol 2012;70(11):1194-1198.

open access

Vol 70, No 11 (2012)
Invasive cardiology
Published online: 2012-11-21
Submitted: 2012-12-28

Abstract

Despite improvements in stent technology, including introduction of drug eluting stents, problem of neointimal hyperplasia and restenosis remains. These phenomena are associated with multiple risk factors and gene polymorphisms. Well known periprocedural risk factors of restenosis such as site of stenting, oversizing, implantation of overlapping stents along with change in vessel geometry affect blood flow conditions. Both experimental and clinical studies provide a number of arguments regarding importance of hemodynamic factors like oscillatory shear stresses in the process of restenosis. Computational fluid dynamic (CFD) enables calculation of indices describing fluid flow including tangential shear stress. This method enables the virtual representation of the physical forces in the flow system and depicting them in graphical form. Flow modeling is used in the process of designing of coronary stents, which allows for the assessment of restenosis risk in the project phase. In the nearest future CFD will be used for prediction of restenosis risk after stent implantation.

Abstract

Despite improvements in stent technology, including introduction of drug eluting stents, problem of neointimal hyperplasia and restenosis remains. These phenomena are associated with multiple risk factors and gene polymorphisms. Well known periprocedural risk factors of restenosis such as site of stenting, oversizing, implantation of overlapping stents along with change in vessel geometry affect blood flow conditions. Both experimental and clinical studies provide a number of arguments regarding importance of hemodynamic factors like oscillatory shear stresses in the process of restenosis. Computational fluid dynamic (CFD) enables calculation of indices describing fluid flow including tangential shear stress. This method enables the virtual representation of the physical forces in the flow system and depicting them in graphical form. Flow modeling is used in the process of designing of coronary stents, which allows for the assessment of restenosis risk in the project phase. In the nearest future CFD will be used for prediction of restenosis risk after stent implantation.
Get Citation

Keywords

restenosis; blood rheology; computational flow dynamics

About this article
Title

The role of haemodynamic factors in the development of in-stent restenosis

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 70, No 11 (2012)

Pages

1194-1198

Published online

2012-11-21

Bibliographic record

Kardiol Pol 2012;70(11):1194-1198.

Keywords

restenosis
blood rheology
computational flow dynamics

Authors

Jarosław Wasilewski
Tadeusz Osadnik
Sylwia Peryt−Stawiarska
Lech Poloński

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