Vol 62, No 4 (2005)
Other
Published online: 2005-12-12
Submitted: 2012-12-28
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Kinetics of chemokines in acute myocardial infarction

Małgorzata Kobusiak-Prokopowicz, Jacek Orzeszko, Grzegorz Mazur, Andrzej Mysiak, Alina Orda, Walentyna Mazurek
Kardiol Pol 2005;62(4):309-314.
Vol 62, No 4 (2005)
Other
Published online: 2005-12-12
Submitted: 2012-12-28

Abstract

Background: Chemokines are supposed to play an important role in the activation of monocytes and in the development of atherosclerosis. There are also suggestions that chemokine-mediated enhanced coagulability may be related to the pathogenesis of acute coronary syndromes.
Aim: To assess the kinetics of 3 chemokines: Monocyte Chemoattractant Protein-1 (MCP-1), Macrophage Inflammatory Protein-1alfa (MIP-1α) and Regulated on Activation Normal T cell Expressed and Secreted (RANTES) in patients with ST-elevation myocardial infarction (STEMI).
Methods: The study group consisted of 40 patients (pts) with STEMI who were divided into 2 groups - 16 pts with anterior MI (AMI) and 24 pts with inferior or lateral MI (IMI). According to the type of received therapy, the pts were divided into 2 other groups: group A - 30 pts treated with thrombolytic agents or primary angioplasty and group B - 10 pts without recanalisation therapy. The control group consisted of 10 healthy volunteers. Blood samples for MCP-1, MIP-1α and RANTES serum levels was taken on admission and 3 h, 24 h, 48 h, 72 h and 7 days afterwards.
Results: The baseline MCP-1 and RANTES levels were significantly higher in pts with STEMI than in controls (1068.9 vs 880.9 pg/ml, p

Abstract

Background: Chemokines are supposed to play an important role in the activation of monocytes and in the development of atherosclerosis. There are also suggestions that chemokine-mediated enhanced coagulability may be related to the pathogenesis of acute coronary syndromes.
Aim: To assess the kinetics of 3 chemokines: Monocyte Chemoattractant Protein-1 (MCP-1), Macrophage Inflammatory Protein-1alfa (MIP-1α) and Regulated on Activation Normal T cell Expressed and Secreted (RANTES) in patients with ST-elevation myocardial infarction (STEMI).
Methods: The study group consisted of 40 patients (pts) with STEMI who were divided into 2 groups - 16 pts with anterior MI (AMI) and 24 pts with inferior or lateral MI (IMI). According to the type of received therapy, the pts were divided into 2 other groups: group A - 30 pts treated with thrombolytic agents or primary angioplasty and group B - 10 pts without recanalisation therapy. The control group consisted of 10 healthy volunteers. Blood samples for MCP-1, MIP-1α and RANTES serum levels was taken on admission and 3 h, 24 h, 48 h, 72 h and 7 days afterwards.
Results: The baseline MCP-1 and RANTES levels were significantly higher in pts with STEMI than in controls (1068.9 vs 880.9 pg/ml, p
Get Citation

Keywords

chemokines - inflammation - acute myocardial infarction

About this article
Title

Kinetics of chemokines in acute myocardial infarction

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 62, No 4 (2005)

Pages

309-314

Published online

2005-12-12

Bibliographic record

Kardiol Pol 2005;62(4):309-314.

Keywords

chemokines - inflammation - acute myocardial infarction

Authors

Małgorzata Kobusiak-Prokopowicz
Jacek Orzeszko
Grzegorz Mazur
Andrzej Mysiak
Alina Orda
Walentyna Mazurek

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