open access

Vol 64, No 10 (2006)
Other
Published online: 2006-10-31
Submitted: 2012-12-28
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Case reports
Reversible dilated cardiomyopathy in a patient with acute, advanced heart failure and intense endothelial inflammatory reaction in endomyocardial biopsy – a case report

Paweł Tyczyński, Zofia T. Bilińska, Zofia Dzielińska, Krzysztof Cedro, Jacek Grzybowski, Ewa Walczak, Ewa Michalak, Teresa Wagner, Witold Rużyłło
Kardiol Pol 2006;64(10):1118-1120.

open access

Vol 64, No 10 (2006)
Other
Published online: 2006-10-31
Submitted: 2012-12-28

Abstract

Inflammatory response of the endothelium has been increasingly recognized in the aetiopathogenesis of sporadic dilated cardiomyopathy (DCM). It has been shown that up to 2/3 of patients with DCM have immunohistological evidence of enhanced activation of the endothelium. We present a case of a middle-aged patient with a history of hypertension and hyperlipidaemia who developed sudden significant left ventricular dysfunction following flu-like syndrome. Endomyocardial biopsy revealed no myocarditis, but immunohistological features of endothelial activation were present. Additionally, increasing titers of IgG antibodies against PvB19 were observed. During 18 months of standard heart failure treatment along with statin therapy, we observed a significant recovery of left ventricular systolic function, and in this way, reversible dilated cardiomyopathy.

Abstract

Inflammatory response of the endothelium has been increasingly recognized in the aetiopathogenesis of sporadic dilated cardiomyopathy (DCM). It has been shown that up to 2/3 of patients with DCM have immunohistological evidence of enhanced activation of the endothelium. We present a case of a middle-aged patient with a history of hypertension and hyperlipidaemia who developed sudden significant left ventricular dysfunction following flu-like syndrome. Endomyocardial biopsy revealed no myocarditis, but immunohistological features of endothelial activation were present. Additionally, increasing titers of IgG antibodies against PvB19 were observed. During 18 months of standard heart failure treatment along with statin therapy, we observed a significant recovery of left ventricular systolic function, and in this way, reversible dilated cardiomyopathy.
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Keywords

dilated cardiomyopathy; hypertension; hyperlipidaemia; endomyocardial biopsy; endothelial activation

About this article
Title

Case reports
Reversible dilated cardiomyopathy in a patient with acute, advanced heart failure and intense endothelial inflammatory reaction in endomyocardial biopsy – a case report

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 64, No 10 (2006)

Pages

1118-1120

Published online

2006-10-31

Bibliographic record

Kardiol Pol 2006;64(10):1118-1120.

Keywords

dilated cardiomyopathy
hypertension
hyperlipidaemia
endomyocardial biopsy
endothelial activation

Authors

Paweł Tyczyński
Zofia T. Bilińska
Zofia Dzielińska
Krzysztof Cedro
Jacek Grzybowski
Ewa Walczak
Ewa Michalak
Teresa Wagner
Witold Rużyłło

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