open access

Vol 64, No 10 (2006)
Other
Published online: 2006-10-31
Submitted: 2012-12-28
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Original article
Platelet aggregation and P-selectin levels during exercise treadmill test in patients with ischaemic heart disease

Małgorzata Kobusiak-Prokopowicz, Wiktor Kuliczkowski, Bożena Karolko, Iwona Prajs, Walentyna Mazurek
Kardiol Pol 2006;64(10):1094-1100.

open access

Vol 64, No 10 (2006)
Other
Published online: 2006-10-31
Submitted: 2012-12-28

Abstract

Introduction: Coronary artery disease (CAD) is associated with higher platelet activation sometimes despite aspirin use. There are conflicting data concerning platelet activation course during physical exercise in patients on aspirin with CAD. Aim: To assess platelet activation pattern during physical exercise in patients with CAD. Methods: The study included 35 patients (20 men, 15 women) aged 64.7±10 years with CAD (CCS II) on aspirin treatment (75 mg daily) and a control group of 10 healthy subjects adjusted for age and gender. Treadmill testing was performed using the Bruce protocol. Platelet aggregation was measured with optical aggregation with the agonists ADP (10 µM), collagen (2 µg/ml) and arachidonic acid (0.5 mg/ml) before and at peak exercise; P-selectin platelet and soluble expression (basal and after stimulation with thrombin) was assessed with cytofluorometry before, at peak exercise and 1 hour after. Results: There were no differences in collagen and ADP aggregation between patients and the control group. There was a significant increase of ADP aggregation at peak exercise in the control group (p

Abstract

Introduction: Coronary artery disease (CAD) is associated with higher platelet activation sometimes despite aspirin use. There are conflicting data concerning platelet activation course during physical exercise in patients on aspirin with CAD. Aim: To assess platelet activation pattern during physical exercise in patients with CAD. Methods: The study included 35 patients (20 men, 15 women) aged 64.7±10 years with CAD (CCS II) on aspirin treatment (75 mg daily) and a control group of 10 healthy subjects adjusted for age and gender. Treadmill testing was performed using the Bruce protocol. Platelet aggregation was measured with optical aggregation with the agonists ADP (10 µM), collagen (2 µg/ml) and arachidonic acid (0.5 mg/ml) before and at peak exercise; P-selectin platelet and soluble expression (basal and after stimulation with thrombin) was assessed with cytofluorometry before, at peak exercise and 1 hour after. Results: There were no differences in collagen and ADP aggregation between patients and the control group. There was a significant increase of ADP aggregation at peak exercise in the control group (p
Get Citation

Keywords

platelet aggregation; P-selectin; coronary artery disease

About this article
Title

Original article
Platelet aggregation and P-selectin levels during exercise treadmill test in patients with ischaemic heart disease

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 64, No 10 (2006)

Pages

1094-1100

Published online

2006-10-31

Bibliographic record

Kardiol Pol 2006;64(10):1094-1100.

Keywords

platelet aggregation
P-selectin
coronary artery disease

Authors

Małgorzata Kobusiak-Prokopowicz
Wiktor Kuliczkowski
Bożena Karolko
Iwona Prajs
Walentyna Mazurek

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