open access

Vol 64, No 4 (2006)
Other
Published online: 2006-04-27
Submitted: 2012-12-28
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ORIGINAL ARTICLE
Diagnosis of ischaemic heart disease by myocardial contrast echocardiography during supine bicycle stress

Jarosław D. Kasprzak
Kardiol Pol 2006;64(4):355-361.

open access

Vol 64, No 4 (2006)
Other
Published online: 2006-04-27
Submitted: 2012-12-28

Abstract


Introduction:
Myocardial contrast echocardiography (MCE) is a new imaging modality for diagnosing ischaemic heart disease (IHD).
Aim:
The aim of this study was to assess 1) the feasibility of MCE during supine bicycle stress and 2) the value of this method in the diagnosis of IHD.
Methods:
Supine bicycle stress was performed in 44 consecutive patients (pts) referred for coronary angiography with an intermediate pre-test probability of IHD. MCE was carried out at peak stress and during recovery (once the heart rate returned to the pre-exercise value). During MCE an ultrasound contrast agent (Sonovue®) was administered intravenously in a continuous mode using an infusion pump (BR-INF 100, Bracco Research). The acquired images were qualitatively assessed for perfusion and wall motion abnormalities. The 18-segment division of the left ventricle was used in the analysis. Coronary angiography was performed in all pts within 15 days of the exercise test. A quantitative analysis of coronary artery stenoses was carried out using the CAAS system.
Results:
MCE could not be performed in 2 pts due to technical difficulties. Coronary angiography revealed significant coronary artery stenosis in 25 pts. The sensitivity and specificity of MCE in the diagnosis of IHD were 92.0% and 82.4%, respectively. The positive and negative predictive values were found to be 88.5% and 87.5%, respectively, while the agreement between coronary angiography and MCE was 88.1% (κ=0.75).
Conclusions:
MCE during supine bicycle stress and continuous intravenous administration of an ultrasound contrast agent is a feasible technique and allows accurate diagnosis of IHD in pts in whom the pre-test probability of the disease is intermediate.

Abstract


Introduction:
Myocardial contrast echocardiography (MCE) is a new imaging modality for diagnosing ischaemic heart disease (IHD).
Aim:
The aim of this study was to assess 1) the feasibility of MCE during supine bicycle stress and 2) the value of this method in the diagnosis of IHD.
Methods:
Supine bicycle stress was performed in 44 consecutive patients (pts) referred for coronary angiography with an intermediate pre-test probability of IHD. MCE was carried out at peak stress and during recovery (once the heart rate returned to the pre-exercise value). During MCE an ultrasound contrast agent (Sonovue®) was administered intravenously in a continuous mode using an infusion pump (BR-INF 100, Bracco Research). The acquired images were qualitatively assessed for perfusion and wall motion abnormalities. The 18-segment division of the left ventricle was used in the analysis. Coronary angiography was performed in all pts within 15 days of the exercise test. A quantitative analysis of coronary artery stenoses was carried out using the CAAS system.
Results:
MCE could not be performed in 2 pts due to technical difficulties. Coronary angiography revealed significant coronary artery stenosis in 25 pts. The sensitivity and specificity of MCE in the diagnosis of IHD were 92.0% and 82.4%, respectively. The positive and negative predictive values were found to be 88.5% and 87.5%, respectively, while the agreement between coronary angiography and MCE was 88.1% (κ=0.75).
Conclusions:
MCE during supine bicycle stress and continuous intravenous administration of an ultrasound contrast agent is a feasible technique and allows accurate diagnosis of IHD in pts in whom the pre-test probability of the disease is intermediate.
Get Citation

Keywords

myocardial contrast echocardiography; ischaemic heart disease; stress echocardiography

About this article
Title

ORIGINAL ARTICLE
Diagnosis of ischaemic heart disease by myocardial contrast echocardiography during supine bicycle stress

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 64, No 4 (2006)

Pages

355-361

Published online

2006-04-27

Bibliographic record

Kardiol Pol 2006;64(4):355-361.

Keywords

myocardial contrast echocardiography
ischaemic heart disease
stress echocardiography

Authors

Jarosław D. Kasprzak

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