open access

Vol 64, No 8 (2006)
Other
Published online: 2006-09-13
Submitted: 2012-12-28
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Original article
Increased levels of inflammatory markers in hypertensives with target organ damage

Marek Jastrzębski, Danuta Czarnecka, Marek Rajzer, Kalina Kawecka-Jaszcz
Kardiol Pol 2006;64(8):802-809.

open access

Vol 64, No 8 (2006)
Other
Published online: 2006-09-13
Submitted: 2012-12-28

Abstract

Introduction: Inflammatory markers have been reported to be elevated in hypertension. Aim: We compared levels of inflammatory markers between hypertensives (HT) with target organ damage (TOD) but without associated clinical conditions (ACC), n=55, HT with ACC, n=42, HT without TOD/ACC, n=22 and normotensive controls, n=41. Methods: Serum levels of CRP, fibrinogen, TNF-a and anti-HSP60 antibodies were measured. Hypertensive complications were assessed on the basis of clinical history and the following investigations: M-mode echocardiography (left ventricular hypertrophy), Doppler: mitral and pulmonary vein flow and isovolumetric relaxation time (diastolic dysfunction), vascular ultrasound (common carotid artery intima-media thickness - IMT), pulse wave velocity (carotid-femoral arterial stiffness) and creatinine concentration (renal function). Results: HT with TOD had higher concentrations of CRP than controls (1.71 vs 0.76 mg/l, p

Abstract

Introduction: Inflammatory markers have been reported to be elevated in hypertension. Aim: We compared levels of inflammatory markers between hypertensives (HT) with target organ damage (TOD) but without associated clinical conditions (ACC), n=55, HT with ACC, n=42, HT without TOD/ACC, n=22 and normotensive controls, n=41. Methods: Serum levels of CRP, fibrinogen, TNF-a and anti-HSP60 antibodies were measured. Hypertensive complications were assessed on the basis of clinical history and the following investigations: M-mode echocardiography (left ventricular hypertrophy), Doppler: mitral and pulmonary vein flow and isovolumetric relaxation time (diastolic dysfunction), vascular ultrasound (common carotid artery intima-media thickness - IMT), pulse wave velocity (carotid-femoral arterial stiffness) and creatinine concentration (renal function). Results: HT with TOD had higher concentrations of CRP than controls (1.71 vs 0.76 mg/l, p
Get Citation

Keywords

hypertension; target organ damage; inflammation; fibrinogen; C-reactive protein; tumour necrosis factor

About this article
Title

Original article
Increased levels of inflammatory markers in hypertensives with target organ damage

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 64, No 8 (2006)

Pages

802-809

Published online

2006-09-13

Bibliographic record

Kardiol Pol 2006;64(8):802-809.

Keywords

hypertension
target organ damage
inflammation
fibrinogen
C-reactive protein
tumour necrosis factor

Authors

Marek Jastrzębski
Danuta Czarnecka
Marek Rajzer
Kalina Kawecka-Jaszcz

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