open access

Vol 64, No 8 (2006)
Other
Published online: 2006-09-13
Submitted: 2012-12-28
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Original paper
Endothelium-dependent acetylcholine-induced vasodilatory response of saphenous vein grafts

Andrzej Ciszewski, Cezary Kępka, Walerian Piotrowski, Adam Witkowski
Kardiol Pol 2006;64(8):786-790.

open access

Vol 64, No 8 (2006)
Other
Published online: 2006-09-13
Submitted: 2012-12-28

Abstract

Introduction: It has been suggested that endothelial dysfunction is critical to saphenous vein graft (SVG) occlusion. Aim: To evaluate in vivo endothelium-mediated vasoreactivity in angiographically non-stenotic SVG. Methods: The group consisted of 31 patients (pts), aged 58.7±8.7 years, 54±38 months after coronary bypass surgery. In each patient one angiographically normal SVG was selected for the study. Endothelium-dependent vasoreactivity was investigated with acetylcholine (Ach) 50 µg intragraft infusion. Graft diameter changes were measured by quantitative computer angiography (QCA). Results: In 17 (54.8%) pts there was a significant reduction in graft diameter following Ach infusion, from 3.8±0.7 to 3.2±0.7 mm (p=0.0001), whereas in 4 (12.9%) pts there were no diameter changes (3.2±0.7 mm). In the 10 remaining pts (32.3%) we found graft dilatation from 3.5±0.5 mm to 3.9±0.5 mm (p=0.0002). In multivariate linear regression analysis, SVG dilatation positively correlated with a low ratio of graft/artery diameter (p

Abstract

Introduction: It has been suggested that endothelial dysfunction is critical to saphenous vein graft (SVG) occlusion. Aim: To evaluate in vivo endothelium-mediated vasoreactivity in angiographically non-stenotic SVG. Methods: The group consisted of 31 patients (pts), aged 58.7±8.7 years, 54±38 months after coronary bypass surgery. In each patient one angiographically normal SVG was selected for the study. Endothelium-dependent vasoreactivity was investigated with acetylcholine (Ach) 50 µg intragraft infusion. Graft diameter changes were measured by quantitative computer angiography (QCA). Results: In 17 (54.8%) pts there was a significant reduction in graft diameter following Ach infusion, from 3.8±0.7 to 3.2±0.7 mm (p=0.0001), whereas in 4 (12.9%) pts there were no diameter changes (3.2±0.7 mm). In the 10 remaining pts (32.3%) we found graft dilatation from 3.5±0.5 mm to 3.9±0.5 mm (p=0.0002). In multivariate linear regression analysis, SVG dilatation positively correlated with a low ratio of graft/artery diameter (p
Get Citation

Keywords

saphenous vein grafts; endothelial function; vasomotor tone

About this article
Title

Original paper
Endothelium-dependent acetylcholine-induced vasodilatory response of saphenous vein grafts

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 64, No 8 (2006)

Pages

786-790

Published online

2006-09-13

Bibliographic record

Kardiol Pol 2006;64(8):786-790.

Keywords

saphenous vein grafts
endothelial function
vasomotor tone

Authors

Andrzej Ciszewski
Cezary Kępka
Walerian Piotrowski
Adam Witkowski

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