open access

Vol 65, No 10 (2007)
Other
Published online: 2007-10-29
Submitted: 2012-12-28
Get Citation

Original article
Endothelial function in patients with chest pain and normal coronary angiograms

Zofia Grąbczewska, Maciej Thews, Krzysztof Góralczyk, Jacek Kubica
Kardiol Pol 2007;65(10):1199-1206.

open access

Vol 65, No 10 (2007)
Other
Published online: 2007-10-29
Submitted: 2012-12-28

Abstract

Background: A normal coronary angiogram is found in about 20% of patients who undergo coronary angiography due to chest pain. In some of them syndrome X is diagnosed. Endothelial dysfunction is one possible cause of this pathology. Aim: To compare the endothelial function estimated by two different methods in patients with typical or atypical anginal pain and with no chest pain. Methods: Fifty-three patients who underwent coronary angiography due to suspected coronary artery disease and who had a normal coronary angiogram were included in the study: 34 patients had typical anginal pain (group 1) and 19 patients had atypical chest pain (group 2). The control group consisted with 20 subjects without chest pain. The plasma concentration of such endothelial markers as von Willebrand factor (vWF), thrombomodulin (TM), endothelin 1 (ET-1), tissue plasminogen activator (tPA), plasminogen activator inhibitor type 1 (PAI-1) and C-reactive protein were measured. We also determined endothelial-dependent brachial arterial dilatation (flow-mediated dilation, FMD). Results: The groups of patients were different with regard to the factors of known effects on endothelial function but endothelial markers were not different in all groups with two exceptions. The concentration of tPA was the highest in patients with typical chest pain and the concentration of PAI-1 was the highest in patients without chest pain. The FMD values were low in all patients and there were no significant differences in the FMD values between the three analysed groups. We did not find any correlation between the concentration of examined endothelial markers and FMD. A non-significant relationship between the presence of classical risk factors and decreased FMP was observed. We have found a significant relationship between the number of risk factors and FMD, tPA, PAI-1 and hsCRP. Conclusions: The assessment of endothelial function using FMD or estimation of endothelial markers is not useful to differentiate chest pain.

Abstract

Background: A normal coronary angiogram is found in about 20% of patients who undergo coronary angiography due to chest pain. In some of them syndrome X is diagnosed. Endothelial dysfunction is one possible cause of this pathology. Aim: To compare the endothelial function estimated by two different methods in patients with typical or atypical anginal pain and with no chest pain. Methods: Fifty-three patients who underwent coronary angiography due to suspected coronary artery disease and who had a normal coronary angiogram were included in the study: 34 patients had typical anginal pain (group 1) and 19 patients had atypical chest pain (group 2). The control group consisted with 20 subjects without chest pain. The plasma concentration of such endothelial markers as von Willebrand factor (vWF), thrombomodulin (TM), endothelin 1 (ET-1), tissue plasminogen activator (tPA), plasminogen activator inhibitor type 1 (PAI-1) and C-reactive protein were measured. We also determined endothelial-dependent brachial arterial dilatation (flow-mediated dilation, FMD). Results: The groups of patients were different with regard to the factors of known effects on endothelial function but endothelial markers were not different in all groups with two exceptions. The concentration of tPA was the highest in patients with typical chest pain and the concentration of PAI-1 was the highest in patients without chest pain. The FMD values were low in all patients and there were no significant differences in the FMD values between the three analysed groups. We did not find any correlation between the concentration of examined endothelial markers and FMD. A non-significant relationship between the presence of classical risk factors and decreased FMP was observed. We have found a significant relationship between the number of risk factors and FMD, tPA, PAI-1 and hsCRP. Conclusions: The assessment of endothelial function using FMD or estimation of endothelial markers is not useful to differentiate chest pain.
Get Citation

Keywords

endothelium; dysfunction; methods of examination

About this article
Title

Original article
Endothelial function in patients with chest pain and normal coronary angiograms

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 65, No 10 (2007)

Pages

1199-1206

Published online

2007-10-29

Bibliographic record

Kardiol Pol 2007;65(10):1199-1206.

Keywords

endothelium
dysfunction
methods of examination

Authors

Zofia Grąbczewska
Maciej Thews
Krzysztof Góralczyk
Jacek Kubica

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., Świętokrzyska 73 street, 80–180 Gdańsk, Poland

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl