open access

Vol 65, No 11 (2007)
Other
Published online: 2007-11-21
Submitted: 2012-12-28
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Original article
Factors affecting the progression of atherosclerosis in the coronary arteries

Jacek Morka, Maria Krzemińska-Pakuła, Jarosław Drożdż, Aleksandra Morka
Kardiol Pol 2007;65(11):1307-1311.

open access

Vol 65, No 11 (2007)
Other
Published online: 2007-11-21
Submitted: 2012-12-28

Abstract


Background: The induction and progression of atherosclerotic changes is complex and influenced by many factors. The most important are enhanced concentration of LDL cholesterol, enlarged production of free radicals, the inflammatory reaction, endothelial damage, decreased concentration of HDL and increased prothrombotic activity.
Aim: To define the factors influencing the atherosclerotic process in the coronary arteries of patients with coronary disease in serial coronary examinations.
Methods: In the 2nd Department of Cardiology in the Medical University of Lodz, 8989 coronary angiography studies were performed between January 1999 and May 2004. The second intervention in the earlier studied patients was made because of clinical indications. The investigation included 177 consecutive patients (128 men and 49 women) in whom the coronary angiography was executed at least twice.
Results: A significantly larger degree of atherosclerotic process occurred in the group of patients younger than the average age of the studied group (p=0.004), in those with a family history of circulatory diseases (p=0.02), as well as in patients with numerous risk factors of coronary disease (p=0.01). In the well-fitted model of the prediction of progression of vascular changes, according to the Gensini Score in individual time (p

Abstract


Background: The induction and progression of atherosclerotic changes is complex and influenced by many factors. The most important are enhanced concentration of LDL cholesterol, enlarged production of free radicals, the inflammatory reaction, endothelial damage, decreased concentration of HDL and increased prothrombotic activity.
Aim: To define the factors influencing the atherosclerotic process in the coronary arteries of patients with coronary disease in serial coronary examinations.
Methods: In the 2nd Department of Cardiology in the Medical University of Lodz, 8989 coronary angiography studies were performed between January 1999 and May 2004. The second intervention in the earlier studied patients was made because of clinical indications. The investigation included 177 consecutive patients (128 men and 49 women) in whom the coronary angiography was executed at least twice.
Results: A significantly larger degree of atherosclerotic process occurred in the group of patients younger than the average age of the studied group (p=0.004), in those with a family history of circulatory diseases (p=0.02), as well as in patients with numerous risk factors of coronary disease (p=0.01). In the well-fitted model of the prediction of progression of vascular changes, according to the Gensini Score in individual time (p
Get Citation

Keywords

arteriosclerosis; progression of atherosclerotic process; coronary arteries

About this article
Title

Original article
Factors affecting the progression of atherosclerosis in the coronary arteries

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 65, No 11 (2007)

Pages

1307-1311

Published online

2007-11-21

Bibliographic record

Kardiol Pol 2007;65(11):1307-1311.

Keywords

arteriosclerosis
progression of atherosclerotic process
coronary arteries

Authors

Jacek Morka
Maria Krzemińska-Pakuła
Jarosław Drożdż
Aleksandra Morka

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