open access

Vol 65, No 2 (2007)
Other
Published online: 2007-02-23
Submitted: 2012-12-28
Get Citation

Original article
Effects of pathogenic factors on prognosis in patients with prosthetic valve endocarditis

Elżbieta Abramczuk, Tomasz Hryniewiecki, Janina Stępińska
Kardiol Pol 2007;65(2):115-122.

open access

Vol 65, No 2 (2007)
Other
Published online: 2007-02-23
Submitted: 2012-12-28

Abstract


Introduction: Despite progress in medicine, the prevalence of infective endocarditis (IE) in patients with prosthetic valves (PVE) has not decreased. Positive blood and valve cultures are one of the most important diagnostic criteria of IE. There are no unambiguous data regarding the influence of pathogenic factors on prognosis.
Aim: To analyse blood and valve cultures in patients with PVE and assess their impact on the risk of early and late deaths as well as IE relapse.
Methods: The study group consisted of 71 PVE patients. Infective endocarditis was diagnosed based on the Polish Cardiac Society guidelines. Early and late mortality as well as IE relapse were analysed in patients hospitalised between 1988 and 1998.
Results: Positive blood cultures were found in 55 (77.5%) patients. Early mortality was 15.5% (11 deaths). Coagulase-negative Staphylococcus infection was an independent risk factor of early death (p=0.02). During long-term follow-up 8 (13.3%) patients died. The risk of late death increased with positive valve culture (p=0.04). Recurrence of IE was diagnosed in 6 (10%) patients. Staphylococcus epidermidis was a risk factor of disease relapse (p=0.03). Six-year survival was 73%.
Conclusions: 1. Coagulase-negative Staphylococcus aetiology increases the risk of early death in patients with PVE. 2. Pathogenic factors did not influence the risk of late death. 3. The risk of late death was increased with positive valve culture with negative blood cultures. 4. Staphylococcus epidermidis aetiology increases the risk of PVE relapse.

Abstract


Introduction: Despite progress in medicine, the prevalence of infective endocarditis (IE) in patients with prosthetic valves (PVE) has not decreased. Positive blood and valve cultures are one of the most important diagnostic criteria of IE. There are no unambiguous data regarding the influence of pathogenic factors on prognosis.
Aim: To analyse blood and valve cultures in patients with PVE and assess their impact on the risk of early and late deaths as well as IE relapse.
Methods: The study group consisted of 71 PVE patients. Infective endocarditis was diagnosed based on the Polish Cardiac Society guidelines. Early and late mortality as well as IE relapse were analysed in patients hospitalised between 1988 and 1998.
Results: Positive blood cultures were found in 55 (77.5%) patients. Early mortality was 15.5% (11 deaths). Coagulase-negative Staphylococcus infection was an independent risk factor of early death (p=0.02). During long-term follow-up 8 (13.3%) patients died. The risk of late death increased with positive valve culture (p=0.04). Recurrence of IE was diagnosed in 6 (10%) patients. Staphylococcus epidermidis was a risk factor of disease relapse (p=0.03). Six-year survival was 73%.
Conclusions: 1. Coagulase-negative Staphylococcus aetiology increases the risk of early death in patients with PVE. 2. Pathogenic factors did not influence the risk of late death. 3. The risk of late death was increased with positive valve culture with negative blood cultures. 4. Staphylococcus epidermidis aetiology increases the risk of PVE relapse.
Get Citation

Keywords

prosthetic valve infective endocarditis; pathogenic factors; prognosis

About this article
Title

Original article
Effects of pathogenic factors on prognosis in patients with prosthetic valve endocarditis

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 65, No 2 (2007)

Pages

115-122

Published online

2007-02-23

Bibliographic record

Kardiol Pol 2007;65(2):115-122.

Keywords

prosthetic valve infective endocarditis
pathogenic factors
prognosis

Authors

Elżbieta Abramczuk
Tomasz Hryniewiecki
Janina Stępińska

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., Świętokrzyska 73 street, 80–180 Gdańsk, Poland

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl