open access

Vol 65, No 4 (2007)
Other
Published online: 2007-04-26
Submitted: 2012-12-28
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Original article
NT-proBNP plasma levels and echocardiographic assessment of cardiac function in patients after renal transplantation

Zbigniew Zbróg, Adam Szuflet, Agnieszka Rybińska, Małgorzata Tomaszek, Teresa Pierzchalska-Mudyna, Grzegorz Piotrowski, Paulina Sikorska-Radek, Zenon Gawor, Józef Matych
Kardiol Pol 2007;65(4):345-351.

open access

Vol 65, No 4 (2007)
Other
Published online: 2007-04-26
Submitted: 2012-12-28

Abstract

Background: Cardiovascular diseases are the most important causes of death in patients with chronic renal disease (CRD). Successful renal transplantation (RTx) corrects water and electrolyte disturbances and decreases or eliminates anaemia. It favourably influences cardiac haemodynamics and reduces risk of cardiovascular events. NT-proBNP plasma concentration is one of the prognostic and risk factors in such cases, whereas echocardiography that enables evaluation of the left atrium and ventricle allows detailed analysis of haemodynamic condition of the heart. Aim: To analyse NT-proBNP plasma concentration and selected echocardiographic parameters in patients after RTx at various time intervals after the procedure. Methods: Seventeen patients after RTx were included in the study (age 46.5±16 years, 7 men and 10 women). NT-proBNP plasma level measurements and echocardiography were performed immediately before and at 3 and 6 months after RTx. Additionally, these parameters were assessed in patients receiving cyclosporine A (CsA) and tacrolimus (TAC). Results: NT-proBNP plasma level decreases significantly after RTx (initially 4369±2420, at 3 months 2056±576, at 6 months 1580±572 pg/ml). In the TAC group, a significant reduction was observed at 3 months (from 13291±3563 to 1845±1022 pg/ml). In patients treated with CsA reduction occurred at 6 months after RTx (from 9447±3369 to 1246±436 pg/ml). At six-month follow-up significant changes in ejection fraction were not found. However, a significant increase in LV mass in CsA patients was observed. Conclusions: Reduction of NT-proBNP levels seems to be more the result of transplanted kidney function than of an improvement in circulation. Significant LV mass increase in CsA patients may be a result of higher blood pressure levels observed before and after RTx.

Abstract

Background: Cardiovascular diseases are the most important causes of death in patients with chronic renal disease (CRD). Successful renal transplantation (RTx) corrects water and electrolyte disturbances and decreases or eliminates anaemia. It favourably influences cardiac haemodynamics and reduces risk of cardiovascular events. NT-proBNP plasma concentration is one of the prognostic and risk factors in such cases, whereas echocardiography that enables evaluation of the left atrium and ventricle allows detailed analysis of haemodynamic condition of the heart. Aim: To analyse NT-proBNP plasma concentration and selected echocardiographic parameters in patients after RTx at various time intervals after the procedure. Methods: Seventeen patients after RTx were included in the study (age 46.5±16 years, 7 men and 10 women). NT-proBNP plasma level measurements and echocardiography were performed immediately before and at 3 and 6 months after RTx. Additionally, these parameters were assessed in patients receiving cyclosporine A (CsA) and tacrolimus (TAC). Results: NT-proBNP plasma level decreases significantly after RTx (initially 4369±2420, at 3 months 2056±576, at 6 months 1580±572 pg/ml). In the TAC group, a significant reduction was observed at 3 months (from 13291±3563 to 1845±1022 pg/ml). In patients treated with CsA reduction occurred at 6 months after RTx (from 9447±3369 to 1246±436 pg/ml). At six-month follow-up significant changes in ejection fraction were not found. However, a significant increase in LV mass in CsA patients was observed. Conclusions: Reduction of NT-proBNP levels seems to be more the result of transplanted kidney function than of an improvement in circulation. Significant LV mass increase in CsA patients may be a result of higher blood pressure levels observed before and after RTx.
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Keywords

renal transplantation; immunosupression; NT-proBNP; echocardiography

About this article
Title

Original article
NT-proBNP plasma levels and echocardiographic assessment of cardiac function in patients after renal transplantation

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 65, No 4 (2007)

Pages

345-351

Published online

2007-04-26

Bibliographic record

Kardiol Pol 2007;65(4):345-351.

Keywords

renal transplantation
immunosupression
NT-proBNP
echocardiography

Authors

Zbigniew Zbróg
Adam Szuflet
Agnieszka Rybińska
Małgorzata Tomaszek
Teresa Pierzchalska-Mudyna
Grzegorz Piotrowski
Paulina Sikorska-Radek
Zenon Gawor
Józef Matych

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