open access

Vol 65, No 7 (2007)
Other
Published online: 2007-07-24
Submitted: 2012-12-28
Get Citation

Original article
Haemorheological factors and myocardial reperfusion in patients with ST-elevation myocardial infarction undergoing primary coronary intervention

Jarosław Wasilewski, Bolesław Turczyński, Ludmiła Słowińska, Violetta Kowalik, Tadeusz Osadnik, Lech Poloński
Kardiol Pol 2007;65(7):778-785.

open access

Vol 65, No 7 (2007)
Other
Published online: 2007-07-24
Submitted: 2012-12-28

Abstract


Introduction: The no-reperfusion phenomenon occurs in a considerable number of patients despite restoration of the infarct- -related artery (IRA) patency. Factors responsible for this phenomenon include myocardial structural changes, whereas haemorheological parameters that significantly contribute to microvascular resistance, have not been studied so far.
Aim: To determine the possible relationship between blood and plasma viscosity, red blood cell aggregation and their deformability, and myocardial reperfusion following effective mechanical intervention of IRA.
Methods: The analysis included 23 patients with myocardial infarction treated with primary coronary angioplasty with resultant TIMI (Thrombolysis in Myocardial Infarction) grade 3 flow. Myocardial reperfusion was found effective if myocardial perfusion grade (MPG) was 3. Blood and plasma viscosity were assessed using a Brookfield rotation viscometer. Red blood cell aggregation and deformability were measured with a Laser Optical Rotational Cell Analyzer (LORCA). Patients were divided into two groups with respect to obtained MPG: reperfusion group (14 subjects) and no-reperfusion group (9 patients).
Results: Corrected whole blood viscosity and plasma viscosity were significantly higher in the no-reperfusion group and exceeded the values obtained in the reperfused patients by 14% (p

Abstract


Introduction: The no-reperfusion phenomenon occurs in a considerable number of patients despite restoration of the infarct- -related artery (IRA) patency. Factors responsible for this phenomenon include myocardial structural changes, whereas haemorheological parameters that significantly contribute to microvascular resistance, have not been studied so far.
Aim: To determine the possible relationship between blood and plasma viscosity, red blood cell aggregation and their deformability, and myocardial reperfusion following effective mechanical intervention of IRA.
Methods: The analysis included 23 patients with myocardial infarction treated with primary coronary angioplasty with resultant TIMI (Thrombolysis in Myocardial Infarction) grade 3 flow. Myocardial reperfusion was found effective if myocardial perfusion grade (MPG) was 3. Blood and plasma viscosity were assessed using a Brookfield rotation viscometer. Red blood cell aggregation and deformability were measured with a Laser Optical Rotational Cell Analyzer (LORCA). Patients were divided into two groups with respect to obtained MPG: reperfusion group (14 subjects) and no-reperfusion group (9 patients).
Results: Corrected whole blood viscosity and plasma viscosity were significantly higher in the no-reperfusion group and exceeded the values obtained in the reperfused patients by 14% (p
Get Citation

Keywords

haemorheological factors; STEMI; PCI; no-reflow

About this article
Title

Original article
Haemorheological factors and myocardial reperfusion in patients with ST-elevation myocardial infarction undergoing primary coronary intervention

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 65, No 7 (2007)

Pages

778-785

Published online

2007-07-24

Bibliographic record

Kardiol Pol 2007;65(7):778-785.

Keywords

haemorheological factors
STEMI
PCI
no-reflow

Authors

Jarosław Wasilewski
Bolesław Turczyński
Ludmiła Słowińska
Violetta Kowalik
Tadeusz Osadnik
Lech Poloński

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., Świętokrzyska 73 street, 80–180 Gdańsk, Poland

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl