open access

Vol 65, No 8 (2007)
Other
Published online: 2007-08-29
Submitted: 2012-12-28
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Original article
Analysis of apoptotic markers Fas/FasL (CD95/CD95L) expression on the lymphocytes in patients with acute coronary syndrome

Anna Bossowska, Artur Bossowski, Bogdan Galar
Kardiol Pol 2007;65(8):883-889.

open access

Vol 65, No 8 (2007)
Other
Published online: 2007-08-29
Submitted: 2012-12-28

Abstract

Background: Acute coronary syndromes are caused by the rupture or erosion of an atherosclerotic plaque which by secreting a variety of proteases is capable of degrading pericellular matrix components induces death of endothelial cells. This mechanism plays the main role in apoptosis.
Aim:
To estimate expression of apoptotic Fas/FasL (CD95/CD95L) on lymphocytes in the peripheral blood.
Methods:
We examined patients with acute myocardial infarction (n=18, mean age 62±8 years), in unstable angina pectoris (n=31, mean age 62±10 years) and in a control group (n=20, mean age 62±9 years) without coronary risk factors and inflammatory condition. All investigations of Fas/FasL were performed by flow cytometry. Inflammatory parameters and standard risk factors were investigated by standard methods (ELISA).
Results:
The analysis revealed a higher expression of Fas and FasL molecules on the lymphocytes from patients with acute myocardial infarction (p

Abstract

Background: Acute coronary syndromes are caused by the rupture or erosion of an atherosclerotic plaque which by secreting a variety of proteases is capable of degrading pericellular matrix components induces death of endothelial cells. This mechanism plays the main role in apoptosis.
Aim:
To estimate expression of apoptotic Fas/FasL (CD95/CD95L) on lymphocytes in the peripheral blood.
Methods:
We examined patients with acute myocardial infarction (n=18, mean age 62±8 years), in unstable angina pectoris (n=31, mean age 62±10 years) and in a control group (n=20, mean age 62±9 years) without coronary risk factors and inflammatory condition. All investigations of Fas/FasL were performed by flow cytometry. Inflammatory parameters and standard risk factors were investigated by standard methods (ELISA).
Results:
The analysis revealed a higher expression of Fas and FasL molecules on the lymphocytes from patients with acute myocardial infarction (p
Get Citation

Keywords

myocardial infarction; unstable angina; apoptosis

About this article
Title

Original article
Analysis of apoptotic markers Fas/FasL (CD95/CD95L) expression on the lymphocytes in patients with acute coronary syndrome

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 65, No 8 (2007)

Pages

883-889

Published online

2007-08-29

Bibliographic record

Kardiol Pol 2007;65(8):883-889.

Keywords

myocardial infarction
unstable angina
apoptosis

Authors

Anna Bossowska
Artur Bossowski
Bogdan Galar

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