open access

Vol 65, No 9 (2007)
Other
Published online: 2007-10-03
Submitted: 2012-12-28
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Original article
Synergistic effects of apolipoprotein E gene epsilon polymorphism and some conventional risk factors on premature ischaemic heart disease development

Anna Balcerzyk, Iwona Żak, Jolanta Krauze
Kardiol Pol 2007;65(9):1058-1065.

open access

Vol 65, No 9 (2007)
Other
Published online: 2007-10-03
Submitted: 2012-12-28

Abstract

Background: Ischaemic heart disease (IHD), which is a clinical manifestation of atherosclerotic changes in coronary arteries, results from the action of multiple genetic and environmental factors. Genetic susceptibility to IHD may be determined by specific polymorphic variants of genes encoding isoforms involved in processes important in the pathogenesis of atherosclerosis. Due to the multifactorial nature of IHD, participation of a single polymorphism in the determination of the disease risk is relatively small. However, it seems that its significance may increase in the presence of a specific genetic or environmental background.

Aim: To evaluate a possible association between the epsilon polymorphism of the apolipoprotein E gene (apo E) and premature IHD in the Polish population as well as to determine whether the genotype may modulate the influence of conventional risk factors on IHD.
Methods: We studied 247 caucasian subjects: 140 patients with angiographically confirmed IHD and 107 blood donors without a history of IHD. Polymorphism epsilon of the apo E gene was genotyped using the PCR-RFLP method.
Results: We observed a tendency to a higher prevalence of the e4 allele and carriers of this allele in the IHD group compared to controls. However, these differences were not statistically significant. We also observed a synergistic effect between e4 allele carrier state and smoking, elevated level of total cholesterol and, to a lower degree – LDL cholesterol, on IHD risk.
Conclusion: Presented data show the synergistic effects between e4 allele carrier state and some traditional risk factors on determining the risk of premature coronary artery disease.

Abstract

Background: Ischaemic heart disease (IHD), which is a clinical manifestation of atherosclerotic changes in coronary arteries, results from the action of multiple genetic and environmental factors. Genetic susceptibility to IHD may be determined by specific polymorphic variants of genes encoding isoforms involved in processes important in the pathogenesis of atherosclerosis. Due to the multifactorial nature of IHD, participation of a single polymorphism in the determination of the disease risk is relatively small. However, it seems that its significance may increase in the presence of a specific genetic or environmental background.

Aim: To evaluate a possible association between the epsilon polymorphism of the apolipoprotein E gene (apo E) and premature IHD in the Polish population as well as to determine whether the genotype may modulate the influence of conventional risk factors on IHD.
Methods: We studied 247 caucasian subjects: 140 patients with angiographically confirmed IHD and 107 blood donors without a history of IHD. Polymorphism epsilon of the apo E gene was genotyped using the PCR-RFLP method.
Results: We observed a tendency to a higher prevalence of the e4 allele and carriers of this allele in the IHD group compared to controls. However, these differences were not statistically significant. We also observed a synergistic effect between e4 allele carrier state and smoking, elevated level of total cholesterol and, to a lower degree – LDL cholesterol, on IHD risk.
Conclusion: Presented data show the synergistic effects between e4 allele carrier state and some traditional risk factors on determining the risk of premature coronary artery disease.
Get Citation

Keywords

apolipoprotein E; ischaemic heart disease; risk factors; gene polymorphism

About this article
Title

Original article
Synergistic effects of apolipoprotein E gene epsilon polymorphism and some conventional risk factors on premature ischaemic heart disease development

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 65, No 9 (2007)

Pages

1058-1065

Published online

2007-10-03

Bibliographic record

Kardiol Pol 2007;65(9):1058-1065.

Keywords

apolipoprotein E
ischaemic heart disease
risk factors
gene polymorphism

Authors

Anna Balcerzyk
Iwona Żak
Jolanta Krauze

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