open access

Vol 66, No 1 (2008)
Other
Published online: 2008-02-04
Submitted: 2012-12-28
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Original article
Cardiac resynchronisation therapy in patients with end-stage heart failure – long-term follow-up

Anna Faran, Ewa Lewicka-Nowak, Alicja Dąbrowska-Kugacka, Maciej Kempa, Sebastian Tybura, Tomasz Królak, Grzegorz Raczak
Kardiol Pol 2008;66(1):19-26.

open access

Vol 66, No 1 (2008)
Other
Published online: 2008-02-04
Submitted: 2012-12-28

Abstract


Background:

Cardiac resynchronisation therapy (CRT) has been shown to be effective in the treatment of patients with end-stage heart failure (HF). However, long-term results of CRT have not yet been validated.
Aim:

To assess the sustained benefit of CRT in patients with end-stage HF at long-term follow-up. In addition, predictors of response to CRT were analysed.
Methods:

Twenty-eight patients with end-stage HF, NYHA class ≥III (≥II in patients with indications for ICD and echocardiographic signs of ventricular mechanical systolic dyssynchrony), left ventricular ejection fraction <35%, QRS duration >120 ms and left bundle branch block morphology received a biventricular device (BiV). In 27 patients LV pacing was achieved via the coronary sinus tributaries and in 1 patient an endocardial LV lead was introduced transseptally. Ten patients received an ICD-CRT device. The control group consisted of 29 patients fulfilling the criteria for ICD-CRT implantation in whom the CRT system was not implanted for various reasons. At baseline, 3 months after implantation, and then every 6 months the following parameters were evaluated: NYHA class, quality of life (QoL) score, QRS duration on surface ECG, and 6-minute walking distance. The need for hospitalisation assessed one year before and one year after implantation was compared. Follow-up was obtained up to 2 years.
Results:

The NYHA class and 6-minute walking test were significantly improved in the CRT group after 3 months and continued to improve gradually until 24 months of follow-up. The QoL improvement at 6 months was sustained over 2 years. Hospitalisation rate due to worsening of HF decreased. One-year and two-year survival were significantly better in the CRT group than in the control group (94 and 87 vs. 80 and 73% respectively). The only predictor of clinical improvement after CRT implantation was baseline NYHA class.
Conclusion:

Clinical improvements with CRT are progressive and sustained over 2 years of follow-up.

Abstract


Background:

Cardiac resynchronisation therapy (CRT) has been shown to be effective in the treatment of patients with end-stage heart failure (HF). However, long-term results of CRT have not yet been validated.
Aim:

To assess the sustained benefit of CRT in patients with end-stage HF at long-term follow-up. In addition, predictors of response to CRT were analysed.
Methods:

Twenty-eight patients with end-stage HF, NYHA class ≥III (≥II in patients with indications for ICD and echocardiographic signs of ventricular mechanical systolic dyssynchrony), left ventricular ejection fraction <35%, QRS duration >120 ms and left bundle branch block morphology received a biventricular device (BiV). In 27 patients LV pacing was achieved via the coronary sinus tributaries and in 1 patient an endocardial LV lead was introduced transseptally. Ten patients received an ICD-CRT device. The control group consisted of 29 patients fulfilling the criteria for ICD-CRT implantation in whom the CRT system was not implanted for various reasons. At baseline, 3 months after implantation, and then every 6 months the following parameters were evaluated: NYHA class, quality of life (QoL) score, QRS duration on surface ECG, and 6-minute walking distance. The need for hospitalisation assessed one year before and one year after implantation was compared. Follow-up was obtained up to 2 years.
Results:

The NYHA class and 6-minute walking test were significantly improved in the CRT group after 3 months and continued to improve gradually until 24 months of follow-up. The QoL improvement at 6 months was sustained over 2 years. Hospitalisation rate due to worsening of HF decreased. One-year and two-year survival were significantly better in the CRT group than in the control group (94 and 87 vs. 80 and 73% respectively). The only predictor of clinical improvement after CRT implantation was baseline NYHA class.
Conclusion:

Clinical improvements with CRT are progressive and sustained over 2 years of follow-up.
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Keywords

cardiac resynchronisation therapy; heart failure

About this article
Title


Original article
Cardiac resynchronisation therapy in patients with end-stage heart failure – long-term follow-up

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 66, No 1 (2008)

Pages

19-26

Published online

2008-02-04

Bibliographic record

Kardiol Pol 2008;66(1):19-26.

Keywords

cardiac resynchronisation therapy
heart failure

Authors

Anna Faran
Ewa Lewicka-Nowak
Alicja Dąbrowska-Kugacka
Maciej Kempa
Sebastian Tybura
Tomasz Królak
Grzegorz Raczak

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