open access

Vol 66, No 11 (2008)
Other
Published online: 2008-11-27
Submitted: 2012-12-28
Get Citation

Original article
Impairment of arterial distensibility in premenopausal women with systemic lupus erythematosus

Mustafa Yildiz, Banu Sahin Yildiz, Mehmet Soy, Hava Tutkan
Kardiol Pol 2008;66(11):1194-1199.

open access

Vol 66, No 11 (2008)
Other
Published online: 2008-11-27
Submitted: 2012-12-28

Abstract


Background and aim: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease affecting young women and is associated with increased frequency of atherosclerotic vascular diseases. Pulse wave velocity (PWV) is an index of arterial stiffness and a marker of cardiovascular events. This study aimed to investigate arterial distensibility using carotid-femoral (aortic) PWV measurements in premenopausal women with SLE.
Methods: We recruited 24 premenopausal women with SLE (SLE duration: 5.3±4.6 years) and 24 age- and sex-matched controls. Aortic PWV was determined by using an automatic device, the Complior Colson (France), which allowed on-line pulse wave recording and automatic calculation of PWV.
Results: The carotid-femoral PWV (8.98&#177;2.05 vs. 8.05&#177;0.94 m/s), systolic blood pressure (117.08&#177;17.12 vs. 106.87&#177;11.96 mmHg), pulse pressure (45.62&#177;11.91 vs. 38.33&#177;9.04 mmHg), heart rate (81.41&#177;9.20 vs. 71.12&#177;10.32 beat/min) and serum glucose levels (89.68&#177;8.12 vs. 73.80&#177;10.72 mg/dl) were significantly higher in premenopausal women with SLE, as compared with control subjects (p=0.04, p=0.02, p=0.02, p=0.001, p <0.001, respectively). We found a significant correlation between PWV and age, body mass index, waist--to-hip ratio, heart rate and blood pressure.
Conclusion: Arterial distensibility is decreased in premenopausal women with SLE.

Abstract


Background and aim: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease affecting young women and is associated with increased frequency of atherosclerotic vascular diseases. Pulse wave velocity (PWV) is an index of arterial stiffness and a marker of cardiovascular events. This study aimed to investigate arterial distensibility using carotid-femoral (aortic) PWV measurements in premenopausal women with SLE.
Methods: We recruited 24 premenopausal women with SLE (SLE duration: 5.3&#177;4.6 years) and 24 age- and sex-matched controls. Aortic PWV was determined by using an automatic device, the Complior Colson (France), which allowed on-line pulse wave recording and automatic calculation of PWV.
Results: The carotid-femoral PWV (8.98&#177;2.05 vs. 8.05&#177;0.94 m/s), systolic blood pressure (117.08&#177;17.12 vs. 106.87&#177;11.96 mmHg), pulse pressure (45.62&#177;11.91 vs. 38.33&#177;9.04 mmHg), heart rate (81.41&#177;9.20 vs. 71.12&#177;10.32 beat/min) and serum glucose levels (89.68&#177;8.12 vs. 73.80&#177;10.72 mg/dl) were significantly higher in premenopausal women with SLE, as compared with control subjects (p=0.04, p=0.02, p=0.02, p=0.001, p <0.001, respectively). We found a significant correlation between PWV and age, body mass index, waist--to-hip ratio, heart rate and blood pressure.
Conclusion: Arterial distensibility is decreased in premenopausal women with SLE.
Get Citation

Keywords

pulse wave velocity; arterial stiffness; systemic lupus erythematosus; inflammation

About this article
Title

Original article
Impairment of arterial distensibility in premenopausal women with systemic lupus erythematosus

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 66, No 11 (2008)

Pages

1194-1199

Published online

2008-11-27

Bibliographic record

Kardiol Pol 2008;66(11):1194-1199.

Keywords

pulse wave velocity
arterial stiffness
systemic lupus erythematosus
inflammation

Authors

Mustafa Yildiz
Banu Sahin Yildiz
Mehmet Soy
Hava Tutkan

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