open access

Vol 66, No 2 (2008)
Other
Published online: 2008-03-03
Submitted: 2012-12-28
Get Citation


Original articles
Association between carotid artery atherosclerosis and coronary artery disease in young females. Reference to sex hormone profile

Beata Kłosiewicz-Wąsek, Leszek Ceremużyński, Lech Poloński, Rafał Łukaszewicz, Jarosław Wasilewski
Kardiol Pol 2008;66(2):127-132.

open access

Vol 66, No 2 (2008)
Other
Published online: 2008-03-03
Submitted: 2012-12-28

Abstract


Background:

Atherosclerosis of coronary and peripheral arteries occurs rarely in premenopausal women. It has been postulated that sex hormones protect the vascular wall.
Aim:

To evaluate whether ultrasound assessment of the changes in the wall of carotid arteries provides any useful information on the severity of atherosclerosis of the coronary vessels as well as whether the atherosclerotic changes in the wall of carotid arteries are accompanied by oestrogen insufficiency in the premenopausal age.
Methods:

The studied group consisted of 65 regularly menstruating women: 21 with coronary artery disease (CAD) revealed by angiography or after myocardial infarction (mean age 44 years) – the CAD group; and 44 healthy woman (mean age 43 years) – the control group. The severity of atherosclerotic changes was determined based on computer-assisted measurement of the intima-media complex thickness (IMC-T) in the common carotid artery. In all women prospective measurement of sex hormone profile was done with enzymatic immunoassay: oestradiol at day 7-9 and day 19-21 of the menstrual cycle and follicle-stimulating hormone (FSH).
Results:

The IMC-T value was greater in the CAD group than the control group (0.696±0.124 mm and 0.518±0.064 mm respectively, p=0.001). The IMC-T (>0.6 mm) was a good indicator of the occurrence of CAD (OR 15.6, 95% CI 3.65-71.1, p <0.0001), with a sensitivity of 73.7% and a specificity of 84.8%. There was a negative correlation between oestradiol level at day 19-21 of the menstrual cycle and IMC-T (r=–0.28, p=0.05).
Conclusions:

The IMC-T value >0.6 mm was found to be a sensitive and specific ultrasound parameter that can be useful in detecting the presence of CAD in premenopausal women. The results of the study also suggest a possible association between hormonal profile and early atherosclerotic changes in carotid arteries in premenopausal women.

Abstract


Background:

Atherosclerosis of coronary and peripheral arteries occurs rarely in premenopausal women. It has been postulated that sex hormones protect the vascular wall.
Aim:

To evaluate whether ultrasound assessment of the changes in the wall of carotid arteries provides any useful information on the severity of atherosclerosis of the coronary vessels as well as whether the atherosclerotic changes in the wall of carotid arteries are accompanied by oestrogen insufficiency in the premenopausal age.
Methods:

The studied group consisted of 65 regularly menstruating women: 21 with coronary artery disease (CAD) revealed by angiography or after myocardial infarction (mean age 44 years) – the CAD group; and 44 healthy woman (mean age 43 years) – the control group. The severity of atherosclerotic changes was determined based on computer-assisted measurement of the intima-media complex thickness (IMC-T) in the common carotid artery. In all women prospective measurement of sex hormone profile was done with enzymatic immunoassay: oestradiol at day 7-9 and day 19-21 of the menstrual cycle and follicle-stimulating hormone (FSH).
Results:

The IMC-T value was greater in the CAD group than the control group (0.696±0.124 mm and 0.518±0.064 mm respectively, p=0.001). The IMC-T (>0.6 mm) was a good indicator of the occurrence of CAD (OR 15.6, 95% CI 3.65-71.1, p <0.0001), with a sensitivity of 73.7% and a specificity of 84.8%. There was a negative correlation between oestradiol level at day 19-21 of the menstrual cycle and IMC-T (r=–0.28, p=0.05).
Conclusions:

The IMC-T value >0.6 mm was found to be a sensitive and specific ultrasound parameter that can be useful in detecting the presence of CAD in premenopausal women. The results of the study also suggest a possible association between hormonal profile and early atherosclerotic changes in carotid arteries in premenopausal women.
Get Citation

Keywords

atherosclerosis; oestrogens; coronary artery disease; premenopause

About this article
Title


Original articles
Association between carotid artery atherosclerosis and coronary artery disease in young females. Reference to sex hormone profile

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 66, No 2 (2008)

Pages

127-132

Published online

2008-03-03

Bibliographic record

Kardiol Pol 2008;66(2):127-132.

Keywords

atherosclerosis
oestrogens
coronary artery disease
premenopause

Authors

Beata Kłosiewicz-Wąsek
Leszek Ceremużyński
Lech Poloński
Rafał Łukaszewicz
Jarosław Wasilewski

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., Świętokrzyska 73 street, 80–180 Gdańsk, Poland

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl