open access

Vol 67, No 1 (2009)
Other
Published online: 2009-01-26
Submitted: 2012-12-28
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Original article
Left ventricular diastolic function assessed with cardiovascular magnetic resonance imaging and exercise capacity in patients with non-obstructive hypertrophic cardiomyopathy

Łukasz A. Małek, Lidia Chojnowska, Mariusz Kłopotowski, Jolanta Miśko, Maciej Dąbrowski, Beata Kuśmierczyk-Droszcz, Renata Mączyńska, Ewa Piotrowicz, Witold Rużyłło
Kardiol Pol 2009;67(1):1-6.

open access

Vol 67, No 1 (2009)
Other
Published online: 2009-01-26
Submitted: 2012-12-28

Abstract


Background: In patients with non-obstructive hypertrophic cardiomyopathy (HCM) and preserved left ventricular (LV) systolic function, diastolic dysfunction is one of the major factors contributing to limited exercise capacity. Cardiovascular magnetic resonance (CMR) imaging has become a useful tool in diagnosis, risk stratification and treatment monitoring in patients with HCM.
Aim: To assess the relationship between simple CMR parameters of LV diastolic function at rest and exercise capacity measured by means of cardiopulmonary exercise testing on a treadmill in patients with non-obstructive HCM and preserved LV systolic function.
Methods: The study included 13 patients with non-obstructive HCM and preserved LV systolic function who underwent cardiopulmonary exercise testing on a treadmill and CMR within 1 month. Analysed parameters of diastolic function included: LV mass index (LVMI), peak filling rate normalised to LV stroke volume index (PFR/LVSVI) and time from the end-systole to PFR normalised to heart rhythm (TPFR).
Results: There was a significant correlation between PFR/LVSVI at rest and peak oxygen uptake (V02peak) (r=0.64, p=0.02). Patients with V02peak below median (

Abstract


Background: In patients with non-obstructive hypertrophic cardiomyopathy (HCM) and preserved left ventricular (LV) systolic function, diastolic dysfunction is one of the major factors contributing to limited exercise capacity. Cardiovascular magnetic resonance (CMR) imaging has become a useful tool in diagnosis, risk stratification and treatment monitoring in patients with HCM.
Aim: To assess the relationship between simple CMR parameters of LV diastolic function at rest and exercise capacity measured by means of cardiopulmonary exercise testing on a treadmill in patients with non-obstructive HCM and preserved LV systolic function.
Methods: The study included 13 patients with non-obstructive HCM and preserved LV systolic function who underwent cardiopulmonary exercise testing on a treadmill and CMR within 1 month. Analysed parameters of diastolic function included: LV mass index (LVMI), peak filling rate normalised to LV stroke volume index (PFR/LVSVI) and time from the end-systole to PFR normalised to heart rhythm (TPFR).
Results: There was a significant correlation between PFR/LVSVI at rest and peak oxygen uptake (V02peak) (r=0.64, p=0.02). Patients with V02peak below median (
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Keywords

hypertrophic cardiomyopathy; diastolic function; cardiovascular magnetic resonance; exercise capacity

About this article
Title

Original article
Left ventricular diastolic function assessed with cardiovascular magnetic resonance imaging and exercise capacity in patients with non-obstructive hypertrophic cardiomyopathy

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 67, No 1 (2009)

Pages

1-6

Published online

2009-01-26

Bibliographic record

Kardiol Pol 2009;67(1):1-6.

Keywords

hypertrophic cardiomyopathy
diastolic function
cardiovascular magnetic resonance
exercise capacity

Authors

Łukasz A. Małek
Lidia Chojnowska
Mariusz Kłopotowski
Jolanta Miśko
Maciej Dąbrowski
Beata Kuśmierczyk-Droszcz
Renata Mączyńska
Ewa Piotrowicz
Witold Rużyłło

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